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4-Azido-L-phenylalanine is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments. 4-Azido-L-phenylalanine contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
| Molecular Weight | 206.2 |
| Formula | C9H10N4O2 |
| CAS Number | 33173-53-4 |
| Solubility (25°C) | DMSO 5 mg/mL (ultrasonic and adjust pH to 2 with HCl) Water 25 mg/mL (ultrasonic and adjust pH to 11 with NaOH) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Mark B Richardson, et al. Synthesis and Explosion Hazards of 4-Azido-l-phenylalanine
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