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AMPK-IN-3 is a potent and selective AMPK inhibitor with IC50 values of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK but does not affect cell viability.
AMPK-IN-3 (0.195313, 0.78125, 3.125, 12.5, 50 μM; 2 h) decreased cellular levels of p-ACC(Ser79) in K562 cells.
| Molecular Weight | 451.56 |
| Formula | C25H33N5O3 |
| CAS Number | 2417674-27-0 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related AMPK Products |
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| Marein
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. |
| Malvidin-3-O-arabinoside chloride
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. |
| AMPK activator 12
AMPK activator 12 is a potent AMPK activator and GDF15 inducer. |
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