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13α,21-Dihydroeurycomanone

Cat. No. M18213
13α,21-Dihydroeurycomanone Structure
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Quality Control & Documentation
Biological Activity

13α,21-Dihydroeurycomanone

Chemical Information
Molecular Weight 410.42
Formula C20H26O9
CAS Number 129587-06-0
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lee Suan Chua, et al. J Chromatogr Sci. LC-PDA-MS/MS-Based Characterization of Key Phytochemicals in Eurycoma Longifolia Roots

[2] Wan-Jie Chung, et al. J Pharm Pharmacol. Comparing the pharmacokinetics of 13α,21-dihydroeurycomanone and eurycomanone exclusively enriched in Eurycoma longifolia extracts and their spermatogenesis enhancement in andrographolide-induced oligospermia in rats

[3] Forough Ebrahimi, et al. Planta Med. 1HNMR-Based Discriminatory Analysis of Eurycoma longifolia from Different Locations and Establishing a Profile for Primary Metabolites Identification and Quassinoids Quantification

[4] Chin-Hoe Teh, et al. J Chromatogr A. Developing a validated liquid chromatography-mass spectrometric method for the simultaneous analysis of five bioactive quassinoid markers for the standardization of manufactured batches of Eurycoma longifolia Jack extract as antimalarial medicaments

[5] Chin-Hoe Teh, et al. Planta Med. Comparative X-ray and conformational analysis of a new crystal of 13α,21-dihydroeurycomanone with eurycomanone from Eurycoma longifolia and their anti-estrogenic activity using the uterotrophic assay

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