| Cat.No. | Name | Information |
|---|---|---|
| M1902 | MG132 | MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM). |
| M2071 | ONX-0914 | Onx-0914 (PR-957) is a selective inhibitor of low molecular weight polypeptide 7 (LMP7), a chymotrypsin subunit of the immune proteasome. Onx-0914 blocks cytokine production and reduces the progression of experimental arthritis. Onx-0914 is a non-competitive irreversible inhibitor of mycobacterium proteasome (Ki=5.2 μM). Onx-0914 activates latent HIV-1 through HF-1-mediated p-TEFb activation. |
| M1686 | Bortezomib (PS-341) | Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. |
| M2193 | Epoxomicin | Epoxomicin (BU-4061T) is a cell-permeable, selective and irreversible proteasome inhibitor with an IC50 value of 4 nM. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. |
| M2035 | IU1 | IU1 is a reversible, small molecule inhibitor of deubiquitination by USP14 that demonstrates an IC50 value of 4-5 μM. |
| M3884 | Celastrol | Celastrol (Tripterin) is a potent antioxidant and anti-inflammatory agent, as well as a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. |
| M52536 | Z-Leu-Leu-Glu-AMC | Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome. |
| M52535 | Z-Leu-Leu-Glu-βNA | Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome. |
| M52534 | Z-Leu-Leu-Leu-AMC | Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome. |
| M52533 | Baceridin | Baceridin is a proteasome inhibitor and a cyclic hexapeptide. |
| M52532 | Z-LLF-CHO | Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM). |
| M42591 | Calpastatin subdomain B | Calpastatin subdomain B is a biological active peptide. |
| M42590 | Davelizomib | Davelizomib is proteasome inhibitor with antineoplastic effect. |
| M42589 | Sadopeptins B | Sadopeptins B is a nature product that could be isolated from Streptomyces sp. |
| M42588 | Sadopeptins A | Sadopeptins A is a nature product that could be isolated from Streptomyces sp. |
| M42587 | Enzyme-IN-1 | Enzyme-IN-1 is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. |
| M41361 | Z-LLY-FMK | Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. |
| M40682 | RA375 | RA375 is an inhibitor of the 26S proteasome subunit RPN13. It can activate UPR signaling, generate ROS and activate apoptosis in cancer cells, and its anti-tumor activity is 10 times higher than that of RA190. |
| M31060 | Acetyl-Calpastatin(184-210)(human) TFA | Acetyl-Calpastatin(184-210)(human) TFA is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively. |
| M29365 | Dazcapistat | Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively. |
| M29182 | Rpn11-IN-1 | Rpn11-IN-1 (Capzimin intermediate) is a potent and selective inhibitor of proteasome subunit Rpn11 with an IC50 of 390 nM. |
| M28912 | (Rac)-Calpain Inhibitor XII | (Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM). (Rac)-Calpain Inhibitor XII has lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). |
| M28862 | MG-262 | MG-262 is a reversible proteasome inhibitor with diverse biological activities. |
| M28727 | KZR-504 | KZR-504 is a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively. KZR-504 is of interest for the treatment of autoimmune disease. |
| M28376 | PR-924 | PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities. |
| M28012 | Acetyl-Calpastatin(184-210)(human) | Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively. |
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