| Cat.No. | Name | Information |
|---|---|---|
| M53031 | Septide | Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a Kd value of 0.55 nM. |
| M45114 | Fosnetupitant chloride monohydrochloride | Fosnetupitant chloride monohydrochloride, the active molecule of the methylene phosphate precursor of Netupitant, is also an NK1 antagonist with pKi values of 9.5 and 6.1 for human NK1 and NK3 receptors, respectively. |
| M45113 | Fosnetupitant | Fosnetupitant (Pronetupitant) is the active molecule of the methylenephosphate precursor of Netupitant and an NK1R receptor antagonist with a pKi value of 9.5 for the human NK1 receptor. |
| M41880 | FR 113680 | FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor. |
| M41879 | NK3R-IN-1 | NK3R-IN-1, a imidazolepiperazine derivative, is an orally active Neurokinin Receptor NK3R inhibitor. |
| M31368 | Osanetant | Osanetant (SR142801) is a potent, selective NK3 receptor antagonist for studies related to schizophrenia. |
| M31367 | SJX-653 | SJX-653 is an orally active, selective NK3R antagonist that inhibits vasodilation and may be used in studies related to hot flashes. |
| M31036 | Hemokinin 1, human TFA | Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia. |
| M31035 | [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA | [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM. |
| M30712 | Rolapitant hydrochloride | Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant hydrochloride does not interact with CYP3A4. Rolapitant hydrochloride shows potent anti-emetic activity in a ferret emesis model. |
| M30501 | Eledoisin | Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors. |
| M30317 | Orvepitant maleate | Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment. |
| M30171 | Hemokinin 1, human | Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia. |
| M28611 | Benzomalvin A | Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with Ki values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively. |
| M28284 | [Lys5,MeLeu9,Nle10]-NKA(4-10) | [Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM. |
| M28243 | RP 67580 | RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a Ki value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation. |
| M22349 | Fosaprepitant | Fosaprepitant is a precursor compound to Aprepitant and a neurokinin-1 receptor (NK1) antagonist that can be used in studies related to nausea and vomiting. |
| M14023 | NKP608 | NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo. |
| M9200 | Ibodutant | Ibodutant (MEN15596) is a potent and selective tachykinin NK2 receptor antagonist with a pKi of 10.1. |
| M9185 | Serlopitant | Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist. |
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