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Ibodutant

Cat. No. M9200
Ibodutant Structure
Synonym:

MEN15596

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ibodutant (MEN15596) is a potent and selective tachykinin NK2 receptor antagonist with a pKi of 10.1. Ibodutant selectively blocks the tachykinin receptor NK2, with blockade practically complete in nanomolar concentrations.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 644.87
Formula C37H48N4O4S
CAS Number 522664-63-7
Purity >98%
Solubility DMSO
Storage at -20°C
References

MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist.
Cialdai C, et al. Eur J Pharmacol. 2006 Nov 7;549(1-3):140-8. PMID: 16979621.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ibodutant, MEN15596 supplier, Neurokinin Receptor, inhibitors

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