Melanocortin Receptor Melanocortin Receptor

Cat.No.	Name	Information
M53079	HS014	HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively.
M53078	HS024	HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively.
M53077	PG106	PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50=210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor.
M50223	Org-2766	Org-2766 is an analog and neurotrophic peptide of the adrenocorticotropic hormone ACTH (4-9) fragment and a melanocortin receptor 2 (MC2R) agonist.Org-2766 can be used in studies related to aging.
M43965	RO27-3225 TFA	RO27-3225 TFA is a potent, selective melanocortin type 4 receptor (MC4R) agonist with EC50s of 1 nM for MC4R and 8 nM for MC1R, with neuroprotective and anti-inflammatory activity, which attenuates gut dysfunction and brain damage.
M43908	PL8905	PL8905 is a selective MCR4 agonist that can be used in studies related to obesity.
M41870	IIIM-8	IIIM-8 is a melanogenesis inhibitor.
M41869	Resomelagon acetate	Resomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC1 and MC3.
M40531	LB54640	LB54640 is a melanocortin receptor-4 (MC4R) antagonist that may be used in studies of obesity associated with POMC deficiency.
M38962	(±)-Eriodictyol	(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent melanogenesis inhibitor with an IC50 of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities.
M31337	PL-8331	PL-8331 is a synthetic peptide that is also an agonist of the melanocortin receptors MC1R and MC5R and can be used in diabetes-related studies.
M31034	PG-931 TFA	PG-931 TFA, an analog of SHU 9119, is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R(IC50=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo.
M30476	ML00253764	ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity.
M30454	PG-931	PG-931, an analog of SHU 9119, is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo.
M30324	Terrein	Terrein is a melanogenesis inhibitor. Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa.
M30113	MK-0493	MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.
M28821	ML-00253764 hydrochloride	ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 µM and 0.103 µM, respectively.
M27800	SNT-207858 free base	SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
M27798	SNT-207858	SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
M27738	SNT-207707	SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

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Melanocortin Receptor Melanocortin Receptor

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