| Cat.No. | Name | Information |
|---|---|---|
| M2358 | 3-Deazaneplanocin A | 3-deazaneplanocin A (DZNeP), an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM. |
| M41691 | Igermetostat | Igermetostat is EZH2 inhibitor, used in cancer research in vivo and in vitro. |
| M41690 | WM-586 | WM-586 is a covalent WDR5 inhibitor that disrupts the binding of WDR5 to MYC. |
| M41689 | PRMT5-IN-28 | PRMT5-IN-28 is an inhibitor of protein arginine methyltransferase 5 (PRMT5) enzyme. |
| M41688 | EML734 | EML734 is a potent and selective PRMT7/9 inhibitor with IC50 values of 315 nM and 0.89 μM, respectively. |
| M41686 | BBDDL2059 | BBDDL2059 is a selective covalent inhibitor of histone methyltransferase EZH2 with an IC50 of 1.5 nM for EZH2-Y641F. |
| M41685 | CARM1-IN-3 | CARM1-IN-3 is a potent and selective co-activator associated arginine methyltransferase (CARM1) inhibitor with IC50 values of 0.07, >25 µM for CARM1 and CARM3, respectively. |
| M41346 | PRMT5-IN-31 | PRMT5-IN-31 is a selective PRMT5 inhibitor (IC50: 0.31 μM). |
| M40717 | UNC0321 | UNC0321 is a high affinity inhibitor of GPCRs and can be used in studies related to chromatin remodeling. It is also a selective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and an IC50 value of 6-9 nM.In addition, UNC0321 also inhibits GLP with an IC50 value of 15-23 nM. |
| M38950 | Tanshindiol C | Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. |
| M31020 | SETDB1-TTD-IN-1 TFA | SETDB1-TTD-IN-1 TFA is a potent, selective and endogenous binder competitive inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD), with a Kd of 88 nM. SETDB1-TTD-IN-1 TFA can be used for the research of biological functions and disease associations of SETDB1-TTD. |
| M31019 | OTS186935 hydrochloride | OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells. |
| M30844 | CPUY074020 | CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity. |
| M30619 | DCLX069 | DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects. |
| M30098 | CSV0C018875 | CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor. CSV0C018875 exhibits lesser cytotoxicity than BIX-01294. |
| M29869 | DC-S239 | DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC50 value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity. |
| M29798 | SETDB1-TTD-IN-1 | SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD), with a Kd of 88 nM. SETDB1-TTD-IN-1 can be used for the research of biological functions and disease associations of SETDB1-TTD. |
| M29754 | RK-701 | RK-701 is an highly selective and non-genotoxic inhibitor of G9a with IC50 value of 23-27 nM. RK-701 selectively up-regulates HbF, γ- Globin, BGLT3 expression, down-regulates H3K9me2 expression. RK-701 also has inhibition for BCL11A and ZBTB7A. |
| M29624 | WDR5-IN-5 | WDR5-IN-5 is an orally active and selective inhibitor of WIN site of WD repeat domain 5 (WDR5). WDR5-IN-5 exhibits anti-proliferative activity towards cancer cells and good pharmacokinetics profile in mice. WDR5-IN-5 shows high affinity to WDR5 and the binding affinity Ki value <0.02 nM. |
| M29447 | MM-589 TFA | MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM. |
| M29405 | EZH2-IN-2 | EZH2-IN-2 is a EZH2 inhibitor, with an IC50 of 64 nM. EZH2-IN-2 can be used for the research of cancer or precancerous condition related to EZH2 activity. |
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