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Dopamine Transporter Dopamine transporter (DAT)

Inhibitor/Activator

Cat.No.  Name Information
M55316 SPD-473 citrate SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior. SPD-473 inhibits the synaptic reuptake of dopamine, serotonin and noradrenaline, making it a triple reuptake inhibitor potentially for the research of Parkinson's Disease.
M31244 Bupropion morpholinol Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities.
M42671 Z1078601926 Z1078601926 is an allosterical inhibitor of human dopamine transporter (hDAT).
M42670 RTI 336 RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor.
M31246 Tesofensine Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC50=6.5 nM), norepinephrine (NE;IC50=1.7 nM), and serotonin (5-HT;IC50=11 nM).
M31245 Dasotraline Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
M30962 (R)-Phenylpiracetam (R)-Phenylpiracetam (MRZ 9547) is a dopamine transporter (DAT) inhibitor (Ki: 14.8 μM; IC50: 65.5 μM). (R)-Phenylpiracetam can be used for the research of the neurological or neuropsychiatric disorders.
M30849 5,7-Dimethoxyluteolin  5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin derivative, is a dopamine transporter (DAT) activator with an EC50 of 3.417 μM.
M28742 Piroheptine hydrochloride  Piroheptine hydrochloride is an anticholinergic agent to inhibit dopamine uptake. Piroheptine hydrochloride prevents loss of striatal dopamine induced by MPTP. Piroheptine hydrochloride can be used for research in Parkinson.
M28653 BMS-466442  BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research.




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