| Cat.No. | Name | Information |
|---|---|---|
| M2565 | PR-619 | PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis. |
| M9871 | GSK2643943A | GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor targeting USP20/Ub-Rho with an IC50 of 160 nM. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC). |
| M9785 | ML364 | ML364 is a small molecule inhibitor of the deubiquitinase USP2 (IC50=1.1 μM, Kd=5.2 μM) with potential anticancer activity. ML364 induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP. |
| M9654 | GRL0617 | GRL0617 is a potent, selective and competitive noncovalent inhibitor of SARS PLPro, with IC50 of 0.6 μM and Ki of 0.49 μM. |
| M9639 | SJB2-043 | Sjb2-043 inhibited USP1/UAF1 complex with IC50 of 544 nM. |
| M6788 | HBX 41108 | HBX 41108 is a selective USP7 inhibitor with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. |
| M3052 | TCID | TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. |
| M2807 | LDN-57444 | LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. |
| M2431 | b-AP15 | b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. *The compound is unstable in solutions, freshly prepared is recommended |
| M2196 | P22077 | P22077 is a selective inhibitor of ubiquitin-specific protease (USP) 7 with EC50 of 8.6 μM. P 22077 also inhibits USP47 with an EC50 of 8.74 μM. |
| M2195 | P005091 | P005091 (P5091) is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 with IC50 of 4.2 μM. |
| M55950 | LDN-91946 | LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM. |
| M55949 | USP5-IN-1 | USP5-IN-1, a potent deubiquitinase USP5 inhibitor, binds to the USP5 ZnF-UBD with a KD of 2.8 μM. |
| M50217 | TNG348 | TNG348 is a novel, oral, potent and selective ubiquitin-specific protease 1 (USP1) inhibitor for studies related to BRCA1/2 mutations and other homologous recombination defect (HRD)+ cancers. |
| M50216 | FT-3171 | FT-3171 is a small molecule ubiquitin-specific protease 1 (USP1) inhibitor targeting a novel DNA damage repair (DDR) pathway for studies related to solid tumors. |
| M49356 | BAY-728 | BAY-728 serves as a negative control for BAY-805, a potent and selective USP21 inhibitor. |
| M49355 | BAY-805 | BAY-805 is a selective inhibitor of the ubiquitin-specific protease USP21 with high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common off-target enzymes. |
| M41456 | USP1-IN-6 | USP1-IN-6 is a USP1 inhibitor (IC50<50 nM). |
| M41455 | USP1-IN-5 | USP1-IN-5 is a USP1 inhibitor (IC50<50 nM). |
| M41454 | CT1113 | CT1113 is a potent USP28 and USP25 inhibitor. |
| M41453 | GK13S | G13KS is a deubiquitinase UCHL1 ligand and inhibitor. |
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