Catalog

Dehydrogenase Dehydrogenase

Inhibitors

Cat.No.	Name	Information
M10434	Olutasidenib (FT-2102)	Olutasidenib (FT-2102) is a highly potent and selective, orally active, brain penetrant mutant Isocitrate dehydrogenase 1 (IDH1) inhibitor, with IC50 values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively.
M10335	IDH-305	IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1(R132) mutation with IC50 values of 27 nM, 28 nM and 6.14 μM for IDH1R132H, IDH1R132C and IDH1WT, respectively.
M10308	Vorasidenib	Vorasidenib (AG-881) is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria.
M10085	Mycophenolate mofetil	Mycophenolate mofetil is an inhibitor of inosine monophosphate dehydrogenase (IMPDH).
M9647	BAY-2402234	BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies, with an IC50 of 1.2 nM.
M9533	DS-1001b	DS-1001b is a potent mutant IDH-1 (Isocitrate Dehydrogenase-1) inhibitor with antitumor activity.
M8958	Ivosidenib	Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.
M6212	BAY-1436032	BAY1436032 is a novel pan-mutant IDH1 inhibitor, it specifically inhibits R-2HG production and colony growth, and induces myeloid differentiation of AML cells.
M6034	Trilostane	Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.
M5663	Fomepizole	Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
M5202	Exherin (ADH-1)	ADH-1 (Exherin) is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities.
M4930	SW033291	SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
M4876	Vidofludimus	Vidofludimus is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH.
M4152	Daidzin	Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone.
M3909	Glycyrrhizic acid	Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.
M3721	ML323	ML323 is a highly potent and selective USP1-UAF1 inhibitor with IC50 of 76 nM.
M3571	Ammonium Glycyrrhizinate	Ammonium Glycyrrhizinate is a unique product derived from Licorice root and has an extremely sweet taste.
M3518	MK-8245	MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
M2563	NSC 14613	NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.
M2371	AGI-6780	AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.
M2297	CPI-613	CPI-613 inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase.
M2229	Leflunomide	Leflunomide is an inhibitor of dihydroorotate dehydrogenase with IC50 of 2.5 μM.
M2067	AGI-5198	AGI-5198 (IDH-C35) is the first highly potent and selective inhibitor of IDH1 R132H and R132C mutants in vitro with IC50 values of 0.07 μM and 0.16 μM, respectively.

Signaling Pathways

Product Type

Dehydrogenase Dehydrogenase

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