Dehydrogenase Dehydrogenase

Inhibitors

Cat.No.	Name	Information
M10434	Olutasidenib (FT-2102)	Olutasidenib (FT-2102) is a highly potent and selective, orally active, brain penetrant mutant Isocitrate dehydrogenase 1 (IDH1) inhibitor, with IC50 values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively.
M10335	IDH-305	IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1(R132) mutation with IC50 values of 27 nM, 28 nM and 6.14 μM for IDH1R132H, IDH1R132C and IDH1WT, respectively.
M10308	Vorasidenib	Vorasidenib (AG-881) is a potent and selective, first-in-Class, brain-penetrant orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria.
M10085	Mycophenolate mofetil	Mycophenolate mofetil is an inhibitor of inosine monophosphate dehydrogenase (IMPDH).
M9647	Orludodstat （BAY-2402234）	BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies, with an IC50 of 1.2 nM.
M9533	DS-1001b	DS-1001b is a potent mutant IDH-1 (Isocitrate Dehydrogenase-1) inhibitor with antitumor activity.
M8958	Ivosidenib	Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.
M6212	BAY-1436032	BAY1436032 is a novel pan-mutant IDH1 inhibitor, it specifically inhibits R-2HG production and colony growth, and induces myeloid differentiation of AML cells.
M6034	Trilostane	Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.
M5663	Fomepizole	Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
M5202	Exherin (ADH-1)	ADH-1 (Exherin) is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities.
M4930	SW033291	SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
M4876	Vidofludimus	Vidofludimus(4SC-101; SC12267) is an immunosuppressant that inhibits DHODH and inhibits il-17 secretion without affecting lymphocyte proliferation.
M4152	Daidzin	Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone.
M3909	Glycyrrhizic acid	Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.
M3721	ML323	ML323 is a highly potent and selective USP1-UAF1 inhibitor with IC50 of 76 nM.
M3571	Ammonium Glycyrrhizinate	Ammonium Glycyrrhizinate is a unique product derived from Licorice root and has an extremely sweet taste.
M3518	MK-8245	MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
M2563	NSC 14613	NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.
M2371	AGI-6780	AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.

Signaling Pathways

Product Type

Dehydrogenase Dehydrogenase

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