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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M10085 | Mycophenolate mofetil | Mycophenolate mofetil is an inhibitor of inosine monophosphate dehydrogenase (IMPDH). |
| M9647 | BAY-2402234 | BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies, with an IC50 of 1.2 nM. |
| M9533 | DS-1001b | DS-1001b is a potent mutant IDH-1 (Isocitrate Dehydrogenase-1) inhibitor with antitumor activity. |
| M8958 | Ivosidenib | Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. |
| M6212 | BAY-1436032 | BAY1436032 specifically inhibits R-2HG production and colony growth, and induces myeloid differentiation of AML cells. |
| M6034 | Trilostane | Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome. |
| M5663 | Fomepizole | Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. |
| M4930 | SW033291 | SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues. |
| M4876 | Vidofludimus | Vidofludimus is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. |
| M4152 | Daidzin | Daidzin is an isoflavone that has anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC50 = 80 nM) and is an effective anti-dipsotropic isoflavone. |
| M3909 | Glycyrrhizic acid | Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root. |
| M3721 | ML323 | ML323 is a highly potent and selective USP1-UAF1 inhibitor with IC50 of 76 nM. |
| M3571 | Ammonium Glycyrrhizinate | Ammonium Glycyrrhizinate is a unique product derived from Licorice root and has an extremely sweet taste. |
| M3518 | MK-8245 | MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. |
| M2563 | NSC 14613 | NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs. |
| M2371 | AGI-6780 | AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM. |
| M2297 | CPI-613 | CPI-613 inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. |
| M2229 | Leflunomide | Leflunomide is an inhibitor of dihydroorotate dehydrogenase with IC50 of 2.5 μM. |
| M2067 | AGI-5198 | AGI-5198 (IDH-C35) is the first highly potent and selective inhibitor of IDH1 R132H and R132C mutants in vitro with IC50 values of 0.07 μM and 0.16 μM, respectively. |
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