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ADH-1 (Exherin) is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities.
In vitro: Incubation with ADH-1 ata concentration of 0.2 mg/ml prevented collagen I-induced cell scattering. Incubating BxPC-3 cells with ADH-1 decreased cell motilityin response to collagen I.
In vivo: ADH-1 (Exherin) prevents N-cadherin overexpressing BxPC-3 cells tumor growth and metastasis in a mouse model for pancreatic cancer at 50 mg/kg (31 per day, 35 per week for 4 weeks) beginning 10days after surgical implantation of the tumor cells.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 570.69 |
| Formula | C22H34N8O6S2 |
| CAS Number | 229971-81-7 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Dehydrogenase Products |
|---|
| MTHFD2-IN-4
MTHFD2-IN-4, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. |
| MTHFD2-IN-4 sodium
MTHFD2-IN-4 sodium, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. |
| MTHFD2-IN-3
MTHFD2-IN-3 is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor. |
| MTHFD2-IN-2
MTHFD2-IN-2 is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor. |
| MTHFD2-IN-1
MTHFD2-IN-1 is a potent methylenetetrahydrofolate dehydrogenase (MTHFD2) inhibitor. |
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