| Cat.No. | Name | Information |
|---|---|---|
| M42274 | HSD17B13-IN-2 | HSD17B13-IN-2 is a potent hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor. |
| M42273 | Clofutriben | Clofutriben (ASP3662) is a 11β-hydroxysteroid dehydrogenase type 1 inhibitor. |
| M30749 | UCK2 Inhibitor-2 | UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells. |
| M29758 | DSM705 | DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound. |
| M29652 | DHODH-IN-21 | DHODH-IN-21 (compound 19) is an orally active selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 1.1 nM. DHODH-IN-21 has anticancer activity and can be used in studies of acute myeloid leukaemia (AML). |
| M29534 | DS44960156 | DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively. |
| M28461 | AGI-12026 | AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma. |
| M22508 | iGP-5 | iGP-5 is a cell-permeable mitochondrial sn-Glycerol 3-phosphate Dehydrogenase (mGPDH) inhibitor. |
| M20802 | 6-Aminonicotinamide | 6-Aminonicotinamide is a competitive inhibitor of NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) with Ki of 0.46 μM. 6-Aminonicotinamide (6AN) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. |
| M20485 | Phenylglyoxal hydrate | Phenylglyoxal is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties. |
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