| Cat.No. | Name | Information |
|---|---|---|
| M39079 | Dihomo-γ-Linolenic acid methyl ester | Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is mainly metabolized to an anti-inflammatory eicosanoid, prostaglandin (PG) E1, via the cyclooxygenase (COX) pathway. Anti-inflammatory and anti-proliferative effects. |
| M39078 | Geranylgeranyl pyrophosphate triammonium | Geranylgeranyl pyrophosphate triammonium is a metabolite involved in protein geranylgeranylation. Geranylgeranyl pyrophosphate triammonium is the common precursor of diterpenoids, for example, Paclitaxel. Geranylgeranyl pyrophosphate triammonium can be used for cancer research. |
| M39077 | Skullcapflavone I | Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a. |
| M39076 | HMMNI | HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class drug that combats protozoan infections. |
| M39075 | Menthofuran | Menthofuran is a proximate toxic metabolite of (R)-(+)-Pulegone. Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase. |
| M39074 | Paeoniflorgenin | Paeoniflorgenin is a deglucosylated metabolite of Paeoniflorin. |
| M39073 | Florfenicol amine | Florfenicol amine is a metabolite of Florfenicol. Florfenicol, a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases. |
| M39072 | Levofloxacin N-oxide | Levofloxacin N-oxide is a minor metabolite of Levofloxacin. Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. |
| M39071 | Gefitinib impurity 1 | Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM). |
| M39070 | Hydroxytanshinone IIA | Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. |
| M39069 | Desmethyl Levofloxacin | Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. |
| M39068 | 15-Acetyl-deoxynivalenol | 15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells. |
| M39067 | 1-Aminohydantoin hydrochloride | 1-Aminohydantoin hydrochloride is a major metabolite of nitrofurantoin in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat, milk et.al. |
| M39066 | Ferulic acid acyl-β-D-glucoside | Ferulic acid acyl-β-D-glucoside is a metabolite of Ferulic Acid. Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively. |
| M39065 | N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide | N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide (Macamide impurity 10) is the impurity of Macamide. |
| M39063 | 16-Hydroxycleroda-3,13-dien-15,16-olide | 16-Hydroxycleroda-3,13-dien-15,16-olide is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. |
| M39062 | Kushenol M | Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a cytochrome P450 (CYP) inhibitor, with IC50 values of 1.29 μM for CYP3A4 in human liver microsomes. |
| M39059 | Isoglycycoumarin | Isoglycycoumarin is a flavonoid isolated from the roots of Glycyrrhiza uralensis. Isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6 (CYP2A6). |
| M39058 | Licopyranocoumarin | Licopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin has potent neuroprotective activities. |
| M39057 | 7-Hydroxyflavanone | 7-Hydroxyflavanone is a potent inhibitor of aromatase (CYP19) activity with the IC50 of 65 μM. 7-Hydroxyflavanone exerts various biological effects, including anticarcinogenic, antioxidant and (anti-)estrogenic effects, and modula |
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