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Dexrazoxane hydrochloride

Cat. No. M2057

Dexrazoxane hydrochloride Structure

Synonym: Cardioxane, ICRF-187, NSC169780, Zinecard

Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Dexrazoxane hydrochloride is a cardioprotective agent. It inhibits DNA topoisomerase II (Topo II) without inducing DNA strand breaks. Dexrazoxane decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 304.73
Formula C11H16N4O4.HCl
CAS Number 149003-01-0
Purity >99%
Solubility DMSO 60 mg/mL
Water 60 mg/mL
Storage at -20°C
References

Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexrazoxane.
Spallarossa P, et al. J Pharmacol Exp Ther. 2010 Jan;332(1):87-96. PMID: 19841470.

Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats.
Lebrecht D, et al. Br J Pharmacol. 2007 Jul;151(6):771-8. PMID: 17519947.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dexrazoxane hydrochloride, Cardioxane, ICRF-187, NSC169780, Zinecard supplier, Topoisomerase, inhibitors

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