Ellagic acid is a selective, ATP-competitive inhibitor of casein kinase 2 (CK2) with IC50 values of 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk and FGR respectively. Ellagic acid has antiproliferative and antioxidant property. Ellagic acid exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutathione S-transferase.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
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