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Beta-Lapachone

Cat. No. M2453
Beta-Lapachone Structure
Synonym:

β-Lapachone, ARQ-501

Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 220 In stock
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Quality Control
Biological Activity

Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 242.27
Formula C15H14O3
CAS Number 4707-32-8
Purity 98.90%
Solubility DMSO 30 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Beta-Lapachone, β-Lapachone, ARQ-501 supplier, Topoisomerase, inhibitors

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