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Cat. No. M1982
Amonafide Structure

AS1413, Quinamed

Size Price Availability Quantity
10mg USD 125 In stock
25mg USD 180 In stock
100mg USD 650 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Amonafide is a DNA intercalating agent and inhibitor of topoisomerase II that has been extensively studied in patients with malignant solid tumors. Topoisomerase II-mediated DNA cleavage induced by Amonafide is affected only slightly (less than 3-fold) by 1 mM ATP, suggeting that Amonafide is an ATP-insensitive topoisomerase II inhibitor in contrast to doxorubicin, etoposide, and mitoxantrone. Amonafide significantly inhibits the growth of HT-29, HeLa, and PC3 cells with IC50 of 4.67 μM, 2.73 μM, and 6.38 μM, respectively. Amonafide (originally AS1413) is a new imide derivative of naphthalic acid. It belongs to the families of drugs called topoisomerase inhibitors and DNA intercalators. Amonafide (trade name Quinamed) has shown significant efficacy for remission induction in patients with sAML in combination with cytarabine. Amonafide is a promising therapeutic candidate directed toward bypassing this common mechanism of compound resistance encountered in the treatment of patients with AML, and possibly in other resistant hematological malignancies as well.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 283.33
Formula C16H17N3O2
CAS Number 69408-81-7
Purity >98%
Solubility DMSO 50 mg/mL
Storage at -20°C

Amonafide, a topoisomerase II inhibitor, is unaffected by P-glycoprotein-mediated efflux.
Chau M, et al. Leuk Res. 2008 Mar;32(3):465-73. PMID: 17826829.

Amonafide: An active agent in the treatment of previously untreated advanced breast cancer--a cancer and leukemia group B study (CALGB 8642).
Costanza ME, et al. Clin Cancer Res. 1995 Jul;1(7):699-704. PMID: 9816035.

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Abmole Inhibitor Catalog 2017

Keywords: Amonafide, AS1413, Quinamed supplier, Topoisomerase, inhibitors

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