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Abmole Inhibitor Catalog 2017

SGLT Sodium-glucose transport proteins

Inhibitors

Cat.No.  Name Information
M9738 LX2761 LX2761 is a locally acting SGLT1 and SGLT2 inhibitor in vitro with IC50 values of 2.2 nM and 2.7 nM for hSGLT1 and hSGLT2, respectively.
M8956 Canagliflozin hemihydrate Canagliflozin hemihydrate (JNJ-28431754; TA 7284) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM.
M5551 Dapagliflozin ((2S)-1,2-propanediol, hydrate) Dapagliflozin(BMS512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) is in development for the treatment of type 2 diabetes mellitus (T2DM).
M5249 LX-4211 LX-4211 is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively.
M4607 Phloretin Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
M4606 Phloridzin Phloridzin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively.
M2667 Empagliflozin Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6.
M2002 Canagliflozin Canagliflozin is a potent, selective sodium glucose co-transporter 2 inhibitor.
M1937 Dapagliflozin Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2).


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