Free shipping on all orders over $ 500

Tofogliflozin (hydrate)

Cat. No. M10441
Tofogliflozin (hydrate) Structure
Synonym:

CSG-452 hydrate

Size Price Availability Quantity
5mg USD 90  USD100 In stock
10mg USD 126  USD140 In stock
50mg USD 432  USD480 In stock
100mg USD 594  USD660 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

Tofogliflozin (CSG-452) hydrate is a potent and highly specific sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 value of 2.9 nM. Tofogliflozin suppressed high glucose-induced ROS generation, MCP-1 gene induction and apoptosis in tubular cells and an antioxidant NAC mimicked the effects of tofogliflozin on high glucoseexposed tubular cells. 

In vivo, Tofogliflozin (0.1-10 mg/kg; oral administration; once daily for 4 weeks) treatment improves hyperglycemia and thereby ameliorated glucose intolerance of the obese diabetic mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 404.45
Formula C22H26O6.H2O
CAS Number 1201913-82-7
Purity >98.5%
Solubility DMSO 80 mg/mL
Water ~1 mg/mL
Storage at -20°C
References

Tofogliflozin, A Highly Selective Inhibitor of SGLT2 Blocks Proinflammatory and Proapoptotic Effects of Glucose Overload on Proximal Tubular Cells Partly by Suppressing Oxidative Stress Generation
Y Ishibashi, et al. Horm Metab Res. 2016 Mar;48(3):191-5. PMID: 26158396.

Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice
Masayuki Suzuki, et al. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701. PMID: 22410641.

Related SGLT Products
Luseogliflozin

Luseogliflozin is a SGLT2 inhibitor, it reduced reabsorption of renal filtered glucose and decreased renal glucose threshold (RTG) in urine to increase urinary glucose excretion.

LX2761

LX2761 is a locally acting SGLT1 and SGLT2 inhibitor in vitro with IC50 values of 2.2 nM and 2.7 nM for hSGLT1 and hSGLT2, respectively.

Canagliflozin hemihydrate

Canagliflozin hemihydrate (JNJ-28431754; TA 7284) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM.

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Dapagliflozin(BMS512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) is in development for the treatment of type 2 diabetes mellitus (T2DM).

LX-4211

LX-4211 is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tofogliflozin (hydrate), CSG-452 hydrate supplier, SGLT, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.