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Ipragliflozin L-Proline

Cat. No. M6200
Ipragliflozin L-Proline Structure
Size Price Availability Quantity
10mg USD 300 In stock
50mg USD 820 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ipragliflozin significantly suppressed body weight gain at 3mg/kg. In the pioglitazone-treated group, a statistically significant increase in body weight was observed compared to CDAA diet-fed vehicle-treated rats.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Wistar rats
Formulation
Dosages 0.3 and 3 mg/kg
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 519.58
Formula C21H21FO5S.C5H9NO2
CAS Number 951382-34-6
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Ipragliflozin, an SGLT2 inhibitor, exhibits a prophylactic effect on hepatic steatosis and fibrosis induced by choline-deficient l-amino acid-defined diet in rats.
Hayashizaki-Someya Y, et al. Eur J Pharmacol. 2015 May 5;754:19-24. PMID: 25701721.

SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats.
Yokono M, et al. Eur J Pharmacol. 2014 Mar 15;727:66-74. PMID: 24486393.

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  Catalog
Abmole Inhibitor Catalog 2017




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