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LX-4211

Cat. No. M5249
LX-4211 Structure
Synonym:

Sotagliflozin

Size Price Availability Quantity
5mg USD 134 In stock
10mg USD 220 In stock
25mg USD 450 In stock
50mg USD 810 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In vitro: LX4211 inhibits [14C]AMG uptake with IC50 of 62.0 nM for mouse SGLT1 and 0.6 nM for mouse SGLT2, respectively. In vivo: In mice, LX4211 (60 mg/kg, p.o.) reduces intestinal glucose absorption by inhibiting SGLT1, resulting in net increases in GLP-1 and PYY release and decreases in GIP release and blood glucose excursions. In nonobese diabetes-prone mice with type 1 diabetes, Sotagliflozin (30 mg/kg) significantly improves glycemic control, without increasing the rate of hypoglycemia measurements.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male albino C57BL/6-Tyrc-Brd mice
Formulation Aqueous 0.1% v/v Tween 80
Dosages ~60 mg/kg
Administration p.o.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 424.94
Formula C21H25ClO5S
CAS Number 1018899-04-1
Purity >99%
Solubility 84 mg/mL in DMSO
Storage at -20°C
References

Sotagliflozin improves glycemic control in nonobese diabetes-prone mice with type 1 diabetes.
Powell DR, et al. Diabetes Metab Syndr Obes. 2015 Feb 26;8:121-7. PMID: 25759591.

LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose.
Powell DR, et al. J Pharmacol Exp Ther. 2013 May;345(2):250-9. PMID: 23487174.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: LX-4211, Sotagliflozin supplier, SGLT, inhibitors

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