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Phloretin

Cat. No. M4607
Phloretin Structure
Synonym:

NSC 407292; RJC 02792

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 45  USD50 In stock
100mg USD 27  USD30 In stock
200mg USD 40.5  USD45 In stock
500mg USD 54  USD60 In stock
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Quality Control
Biological Activity

Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively. Phloretin (NSC 407292; RJC 02792) is extracted from Prunus mandshurica, which has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 274.27
Formula C15H14O5
CAS Number 60-82-2
Purity 99.88%
Solubility DMSO 45 mg/mL
Storage at -20°C
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Tofogliflozin (CSG-452) hydrate is a potent and highly specific sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 value of 2.9 nM.

Luseogliflozin

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LX2761

LX2761 is a locally acting SGLT1 and SGLT2 inhibitor in vitro with IC50 values of 2.2 nM and 2.7 nM for hSGLT1 and hSGLT2, respectively.

Canagliflozin hemihydrate

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Dapagliflozin ((2S)-1,2-propanediol, hydrate)

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Phloretin, NSC 407292; RJC 02792 supplier, SGLT, inhibitors

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