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Prostaglandin Receptor Prostaglandin Receptor

Cat.No.  Name Information
M5929 Prostaglandin E2 Prostaglandin E2 is a vasodilator isolated from prostate gland secretion, working by binding and activating the prostaglandin E2 receptor.
M31219 CAY10580  CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM).
M30662 Treprostinil diethanolamine Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries.
M30400 L-902688  L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors.
M30068 Latanoprost acid  Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.
M20978 Treprostinil sodium Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a stabilized tricyclic analog of prostacyclin and a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. Treprostinil promotes vasodilation and inhibits platelet aggregation in pulmonary and systemic arterial vascular beds, and can be used in studies related to pulmonary arterial hypertension (PAH).
M20392 Bimatoprost Bimatoprost is a synthetic prostaglandin analog as well as a prostaglandin F (FP) receptor agonist (FPA) with IOP-lowering activity for studies related to glaucoma and IOP.
M14045 Selexipag Selexipag (NS-304) is the methanesulfonamide precursor compound of ACT-333679 and an orally effective prostacyclin (PGI2) receptor agonist. It can be used in studies related to pulmonary arterial hypertension.
M10858 MK-2894 MK-2894 is a potent, selective, orally active and high affinity (Ki=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC50=2.5 nM). MK-2894 possesses potent anti-inflammatory activity in animal models of pain/inflammation and can be used for the research of arthritis.
M10803 Butaprost Butaprost is a selective prostaglandin E receptor (EP2) agonist for murine EP2 receptors EC50 The value is 33 nM,Ki The value is 2.4 μM. Butaprost is less active against rodents EP1, EP3 and EP4 receptors. Butaprost mitigates fibrosis by obstructing TGF-β/Smad2 signaling.
M10680 AH 6809 AH 6809 is an antagonist of EP and DP receptors against cloned humans EP1,EP2,EP3-III and DP receptors Ki Values were 1217, 1150, 1597, and 1415 nM, respectively, for mice EP2 receptors Ki The value is 350 nM.
M10679 Evatanepag Evatanepag (CP-533536 free acid) is a potent selective EP2 receptor agonist with an IC50 of 50 nM for rEP2.
M10632 AM211 AM-211 is a novel and potent antagonist of the prostaglandin D2 receptor type 2, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
M10579 Dinoprost tromethamine Dinoprost tromethamine (Prostaglandin F2α tromethamine) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist.
M10481 Omidenepag Omidenepag,a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC50 of 1.1 nM.
M10270 Agnuside Agnuside is a compound isolated from Vitex negundo with anti-arthritic activity.
M10253 Ralinepag Ralinepag (APD811) is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist with EC50 of 8.5 nM, 530 nM and 850 nM for human IP receptor, rat IP receptor and human DP1 receptor, respectively.
M10180 GW627368X GW627368X is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity.
M9854 Taprenepag Taprenepag (CP-544326) is a potent selective prostagenin EP(2) agonist with IC50 of 10 and 15 nM for human and rat EP2, respectively. Taprenepag has higher selectivity for EP2 than other EP receptors (IC50>3200 nM for EP1, EP3 and EP4) and a group of 37 G-protein-coupled receptors.
M9776 Darbufelone Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production, it is also a COX-2 inhibitor potentially for the treatment of rheumatoid arthritis.




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