Prostaglandin Receptor Prostaglandin Receptor

Inhibitors

Cat.No.	Name	Information
M10858	MK-2894	MK-2894 IS AN EFFECTIVE, SELECTIVE, HIGH-AFFINITY (Ki=0.56 nM) of prostaglandin receptor 4 (EP4 receptor) antagonists (IC50=2.5 nM)。 MK-2894 has strong anti-inflammatory activity in animal pain/inflammation models and can be used in arthritis studies.
M10857	MF-766	MF-766 is a highly effective, selective and orally active EP4 antagonist.Ki The value is 0.23 nM. MF-766 behaves as a complete antagonist with its IC in functional detection50 1.4 nM (becomes 1.8 nM when 10% HS is present). MF-766 can be used for cancer and inflammatory disease research.
M10856	MF498	MF498 is a novel selective prostaglandin E4 receptor (EP4 receptor) antagonist with a strong affinity with the EP4 receptor, with a Ki of 0.7 nM.
M10842	KAG-308	KAG-308 is an effective, selective, orallyable EP4 receptor (a subtype of prostaglandin E2 receptor) agonist that inhibits colitis, promotes tissue mucosal healing, and effectively inhibits the production of TNF-α. KAG-308 for human EP4 receptors Ki value and EC50 The values were 2.57 nM and 17 nM, respectively, which were more selective than EP1, EP2, EP3, and IP receptors.
M10827	GSK726701A	GSK726701A is a partial agonist of prostaglandin E2 receptor 4 (EP4),pEC50is 7.4.
M10807	CJ-42794	CJ-42794 is a selective prostaglandin receptor EP4 antagonist that inhibits [3H]-PGE2 binding to EP4 receptors with an average pKi of 8.5 and is more than 200 times more selective than EP1, EP2 and EP3.
M10803	Butaprost	Butaprost is a selective prostaglandin E receptor (EP2) agonist for murine EP2 receptors EC50 The value is 33 nM,Ki The value is 2.4 μM. Butaprost is less active against rodents EP1, EP3 and EP4 receptors. Butaprost mitigates fibrosis by obstructing TGF-β/Smad2 signaling.
M10795	BGC-20-1531 free base	BGC-20-1531 (PGN 1531) free base is a potent selective prostaglandin EP4 receptor antagonists, pKB The value is 7.6. BGC-20-1531 free base has the potential to study migraines.
M10791	BAY-1316957	BAY-1316957 is a potent, selective, orally active antagonist of the prostaglandin E2 receptor subtype 4 (EP4-R) against human EP4-R IC50 15.3 nM. BAY-1316957 has excellent drug metabolism and pharmacokinetic properties and can be used in the study of endometriosis.
M10680	AH 6809	AH 6809 is an antagonist of EP and DP receptors against cloned humans EP1，EP2，EP3-III and DP receptors Ki Values were 1217, 1150, 1597, and 1415 nM, respectively, for mice EP2 receptors Ki The value is 350 nM.
M10679	Evatanepag	Evatanepag (CP-533536 free acid) is a potent selective EP2 receptor agonist with an IC50 of 50 nM for rEP2.
M10632	AM211	AM-211 is a novel and potent antagonist of the prostaglandin D2 receptor type 2, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
M10579	Dinoprost tromethamine	Dinoprost tromethamine (Prostaglandin F2α tromethamine) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist.
M10481	Omidenepag	Omidenepag,a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC50 of 1.1 nM.
M10253	Ralinepag	Ralinepag (APD811) is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist with EC50 of 8.5 nM, 530 nM and 850 nM for human IP receptor, rat IP receptor and human DP1 receptor, respectively.
M10180	GW627368X	GW627368X is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity.
M9854	Taprenepag	Taprenepag (CP-544326) is a potent selective prostagenin EP(2) agonist with IC50 of 10 and 15 nM for human and rat EP2, respectively. Taprenepag has higher selectivity for EP2 than other EP receptors (IC50>3200 nM for EP1, EP3 and EP4) and a group of 37 G-protein-coupled receptors.
M9776	Darbufelone	Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production, it is also a COX-2 inhibitor potentially for the treatment of rheumatoid arthritis.
M9473	RO1138452	RO1138452 is a potent and selective antagonist for both human and rat IP receptors and that is possesses analgesic and anti-inflammatory potential.
M9464	Asapiprant	Asapiprant is a potent and selective DP1 receptor antagonist, with a Ki of 0.44 nM.

Signaling Pathways

Product Type

Prostaglandin Receptor Prostaglandin Receptor

Get to Know Us

Customer Support

Resources

Contact Us