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Prostaglandin E2

Cat. No. M5929

Prostaglandin E2 Structure
Size Price Availability Quantity
10mg USD 135 In stock
50mg USD 800 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In vitro: PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation. In vivo: PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction.

Protocol
Cell Experiment
Cell lines ovulatory follicles
Preparation method All cells and tissues were obtained after ovarian stimulation before (0 h) and 12, 24, or 36 h after administration of an ovulatory dose of hCG.
Concentrations
Incubation time 12, 24, or 36 h
Animal Experiment
Animal models male dogs
Formulation
Dosages 0.1 mg/kg
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 352.47
Formula C20H32O5
CAS Number 363-24-6
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway
Diane M, et al. Hum Reprod Update. 2015 Sep;21(5): 652–670. PMID: 26025453.

Changes in prostaglandin E2 levels in seminal plasma during ejaculation and the effect of exogenous prostaglandin E2 on semen volume in the dog.
Kobayashi M, et al. J Vet Med Sci. 2013;75(9):1249-52. PMID: 23629017.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Prostaglandin E2 supplier, GPR, inhibitors

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