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Prostaglandin E2

Cat. No. M5929
Prostaglandin E2 Structure


Size Price Availability Quantity
5mg USD 87  USD87 In stock
10mg USD 137  USD137 In stock
25mg USD 290  USD290 In stock
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Quality Control
Biological Activity

In vitro: PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation. In vivo: PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction.

Cell Experiment
Cell lines ovulatory follicles
Preparation method All cells and tissues were obtained after ovarian stimulation before (0 h) and 12, 24, or 36 h after administration of an ovulatory dose of hCG.
Incubation time 12, 24, or 36 h
Animal Experiment
Animal models male dogs
Dosages 0.1 mg/kg
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 352.47
Formula C20H32O5
CAS Number 363-24-6
Purity >98%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C

[1] Yu Ting Zhang, et al. J Steroid Biochem Mol Biol. Androgen induces olfactory expression of prostaglandin E 2 receptor Ep1 in the burrow-living fish Bostrychus sinensis

[2] Diane M, et al. Hum Reprod Update. Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway

[3] Kobayashi M, et al. J Vet Med Sci. Changes in prostaglandin E2 levels in seminal plasma during ejaculation and the effect of exogenous prostaglandin E2 on semen volume in the dog.

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Abmole Inhibitor Catalog 2017

Keywords: Prostaglandin E2, PGE2 supplier, Prostaglandin Receptor, inhibitors

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