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Treprostinil sodium

Cat. No. M20978
Treprostinil sodium Structure
Synonym:

UT-15, Remodulin, Orenitram, Tyvaso, Trevyent

Size Price Availability Quantity
5mg USD 110  USD110 In stock
10mg USD 175  USD175 In stock
25mg USD 350  USD350 In stock
50mg USD 560  USD560 In stock
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Quality Control & Documentation
Biological Activity

Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a stabilized tricyclic analog of prostacyclin and a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. Treprostinil promotes vasodilation and inhibits platelet aggregation in pulmonary and systemic arterial vascular beds, and can be used in studies related to pulmonary arterial hypertension (PAH).

Chemical Information
Molecular Weight 412.49
Formula C23H33NaO5
CAS Number 289480-64-4
Solubility (25°C) DMSO 82 mg/mL
Water 82 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Aaron Waxman, et al. N Engl J Med. Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease

[2] R James White, et al. Am J Respir Crit Care Med. Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial

[3] No authors listed. Treprostinil

[4] Matthew Ferrantino, et al. Expert Opin Pharmacother. Inhaled treprostinil sodium for the treatment of pulmonary arterial hypertension

[5] Sarat C Chattaraj. Curr Opin Investig Drugs. Treprostinil sodium Pharmacia

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Keywords: Treprostinil sodium, UT-15, Remodulin, Orenitram, Tyvaso, Trevyent supplier, Prostaglandin Receptor, inhibitors, activators


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