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Treprostinil sodium

Cat. No. M20978
Treprostinil sodium Structure
Synonym:

UT-15, Remodulin, Orenitram, Tyvaso, Trevyent

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 412.49
Formula C23H33NaO5
CAS Number 289480-64-4
Purity >99%
Solubility DMSO 82 mg/mL
Water 82 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog




Keywords: Treprostinil sodium, UT-15, Remodulin, Orenitram, Tyvaso, Trevyent supplier, Prostaglandin Receptor, inhibitors

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