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Alprostadil

Cat. No. M5401
Alprostadil Structure
Synonym:

Prostaglandin-E1

Size Price Availability Quantity
10mg USD 135  USD150 In stock
50mg USD 315  USD350 In stock
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Quality Control
Biological Activity

Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 354.48
Formula C20H34O5
CAS Number 745-65-3
Purity 100.00%
Solubility 60 mg/mL in DMSO
Storage at -20°C
References

Alprostadil for the treatment of impotence.
Hanchanale V, et al. Expert Opin Pharmacother. 2014 Feb;15(3):421-8. PMID: 24369066.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Alprostadil, Prostaglandin-E1 supplier, Prostaglandin Receptor, inhibitors

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