Free shipping on all orders over $ 500

Selexipag

Cat. No. M14045
Selexipag Structure
Synonym:

NS-304; ACT-293987

Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 496.62
Formula
CAS Number 475086-01-2
Purity >99%
Solubility DMSO ≥ 50 mg/mL
Storage at -20°C
References

[1] No authors listed. Selexipag for pulmonary arterial hypertension

[2] Lon Genecand, et al. Selexipag for the treatment of pulmonary arterial hypertension

[3] Evangelia Panagiotidou, et al. An evaluation of selexipag for the treatment of pulmonary hypertension

[4] No authors listed. Selexipag

[5] Olivier Sitbon, et al. Selexipag for the Treatment of Pulmonary Arterial Hypertension

Related Prostaglandin Receptor Products
BAY-6672

BAY-6672 is a potent and selective human prostaglandin F (FP) receptor antagonist with an IC50 value of 11 nM.

BI-671800

BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS.

Treprostinil sodium

Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.

Timapiprant sodium

Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist.

MK-2894 sodium salt

MK-2894 sodium salt is a potent, selective, orally active and high affinity (Ki=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC50=2.5 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: Selexipag, NS-304; ACT-293987 supplier, Prostaglandin Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.