Catalog

Potassium Channel Potassium channel

Inhibitors

Cat.No.	Name	Information
M10516	AUT1	AUT1 is a Kv3 potassium channel modulator which increases whole currents mediated by human Kv3.1b and Kv3.2a channels, with a concomitant leftward shift in the voltage-dependence of activation, while having a less potent effect on hKv3.3 currents.
M9820	2,2,2-Trichloroethanol	2,2,2-Trichloroethanol is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).
M9780	Nigericin	Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore.
M9700	ML213	ML213 (CID-3111211) is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener, with EC50 values of 230 and 510 nM for KV7.2 and KV7.4, respectively.
M9423	CLP290	CLP290 is a novel, orally available KCC2 modulator, highly selective for KCC2 over related Cl- transporters.
M9394	BMS-191011	BMS-191011 is a potent BK_Ca channel opener (large-conductance Ca²⁺-activated potassium channel, K_Ca1.1).
M7926	Minoxidil	Minoxidil activates ATP-activated K⁺ channels; vasodilator; slow or stop hair loss and promote hair regrowth.
M7029	Nigericin sodium salt	Nigericin (NSC 292567) sodium salt is a selective K⁺ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
M6975	ML297	ML297 is a selective K_ir3.1/3.2 (GIRK1/2) channel activator.
M6908	Linopirdine dihydrochloride	Linopirdine dihydrochloride is a Kv7 (KCNQ) channel blocker.
M6052	Vernakalant HCl	Vernakalant Hcl(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.
M5728	Lansoprazole	Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.
M5569	Diazoxide	Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.
M5437	Azimilide	Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.
M5409	Amiodarone	Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
M5368	4-Aminopyridine	4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane.
M5302	ICA069673	ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM.
M4584	Acacetin	Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.
M3714	Repaglinide	Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
M3622	Vernakalant	Vernakalant (RSD-1235) is an investigational mixed ion channel blocker, which can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents.
M3464	Indapamide	Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
M3456	Chlorpromazine hydrochloride	Chlorpromazine hydrochloride is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for nward-rectifying K+ currents and time-independent outward currents
M3415	Nateglinide	Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.
M3399	Gliclazide	Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
M3343	Nicorandil	Nicorandil is potassium channel activator.
M3192	TRAM-34	TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with K_d of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.
M3077	Tolbutamide	Tolbutamide is an inhibitor of cAMP with IC50 of 4 mM, it is also an inhibitor of potassium channel, used for type II diabetes.
M2724	Gliquidone	Gliquidone is an ATP-sensitive K⁺ channel antagonist with IC50 of 27.2 nM.
M2181	ML133 hydrochloride	ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels.
M2043	TAK-438	TAK-438 is a novel and potent potassium-competitive acid blocker (P-CAB) with IC50 of 19 nM.
M1797	Retigabine	Retigabine is a KCNQ/Kv7 potassium channel activator which functions by enhancing potassium currents via stabilizing the open conformation of the Kv7.2-7.3 channels.

Signaling Pathways

Product Type

Potassium Channel Potassium channel

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