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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M5728 | Lansoprazole | Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid. |
| M21491 | Rimtuzalcap | Rimtuzalcap (CAD-1883) is the first (first-in-class), selective small conductance calcium-activated potassium channel (SK channel) positive allosteric regulator. Rimtuzalcap can be used in the study of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA). |
| M21142 | MK-8153 | MK-8153 is a potent, selective and orally active extrarenal medullary potassium channel (ROMK) inhibitor with IC50 values of 5 nM and 34 μM for ROMK EP and hERG EP, respectively.MK-8153 can be used as a diuretic. |
| M21042 | DCPIB | DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM. |
| M20920 | Ajmaline | Ajmaline is an alkaloid that is class Ia antiarrhythmic agent. |
| M20892 | Quinine HCl Dihydrate | Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria. |
| M20808 | ML277 | ML277 (CID-53347902) is a potent activator of KCNQ1 channels with an EC50 of 260 nM and shows >100-fold selectivity over KCNQ2 and KCNQ4. |
| M20786 | Almitrine mesylate | Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM. |
| M20750 | A2764 dihydrochloride | A2764 dihydrochloride is a selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1) with IC50 of 11.8 μM for the activated mTRESK channel. A2764 dihydrochloride has the potential for probing the role of TRESK channel in migraine and nociception. |
| M20746 | A2793 | A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK. |
| M20564 | Tetraethylammonium bromide | Tetraethylammonium bromide is used as the source of tetraethylammonium ions in pharmacological and physiological studies, but is also used in organic chemical synthesis. It blocks selective potassium channels. |
| M20428 | Retigabine 2HCl | Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels. |
| M14264 | VU0134992 hydrochloride | VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. |
| M14263 | Tertiapin-Q | Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1). |
| M14262 | Tannic acid | Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM. |
| M14261 | Senicapoc | Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. |
| M14260 | Quinidine hydrochloride monohydrate | Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K+ channel with an IC50 of 19.9 μM. |
| M14259 | Pinacidil | Pinacidil is a potent activator of potassium channel. |
| M14258 | PAP-1 | PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). |
| M14257 | N-Acetylprocainamide | N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels. |
| M14256 | JNJ 303 | JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. |
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