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Potassium Channel Potassium channel

Inhibitors

Cat.No.  Name Information
M5728 Lansoprazole Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.
M21491 Rimtuzalcap Rimtuzalcap (CAD-1883) is the first (first-in-class), selective small conductance calcium-activated potassium channel (SK channel) positive allosteric regulator. Rimtuzalcap can be used in the study of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA).
M21142 MK-8153 MK-8153 is a potent, selective and orally active extrarenal medullary potassium channel (ROMK) inhibitor with IC50 values of 5 nM and 34 μM for ROMK EP and hERG EP, respectively.MK-8153 can be used as a diuretic.
M21042 DCPIB DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM.
M20920 Ajmaline Ajmaline is an alkaloid that is class Ia antiarrhythmic agent.
M20892 Quinine HCl Dihydrate Quinine HCl Dihydrate is a white crystalline K+ channel blocker, used to treat malaria.
M20808 ML277 ML277 (CID-53347902) is a potent activator of KCNQ1 channels with an EC50 of 260 nM and shows >100-fold selectivity over KCNQ2 and KCNQ4.
M20786 Almitrine mesylate Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.
M20750 A2764 dihydrochloride A2764 dihydrochloride is a selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1) with IC50 of 11.8 μM for the activated mTRESK channel. A2764 dihydrochloride has the potential for probing the role of TRESK channel in migraine and nociception.
M20746 A2793 A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK.
M20564 Tetraethylammonium bromide Tetraethylammonium bromide is used as the source of tetraethylammonium ions in pharmacological and physiological studies, but is also used in organic chemical synthesis. It blocks selective potassium channels.
M20428 Retigabine 2HCl Retigabine is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.
M14264 VU0134992 hydrochloride VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM.
M14263 Tertiapin-Q Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1).
M14262 Tannic acid Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.
M14261 Senicapoc Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM.
M14260 Quinidine hydrochloride monohydrate Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K+ channel with an IC50 of 19.9 μM.
M14259 Pinacidil Pinacidil is a potent activator of potassium channel.
M14258 PAP-1 PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM).
M14257 N-Acetylprocainamide N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.
M14256 JNJ 303 JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM.



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