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Abmole Inhibitor Catalog 2017

Potassium Channel Potassium channel

Inhibitors

Cat.No.  Name Information
M5569 Diazoxide Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.
M5437 Azimilide Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.
M5409 Amiodarone Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
M5368 4-Aminopyridine 4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane.
M5302 ICA069673 ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM.
M3714 Repaglinide Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
M3622 Vernakalant Vernakalant (RSD-1235) is an investigational mixed ion channel blocker, which can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents.
M3456 Chlorpromazine hydrochloride Chlorpromazine hydrochloride is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for nward-rectifying K+ currents and time-independent outward currents
M3415 Nateglinide Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas.
M3399 Gliclazide Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
M3343 Nicorandil Nicorandil is potassium channel activator.
M3192 TRAM-34 TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.
M3077 Tolbutamide Tolbutamide is an inhibitor of cAMP with IC50 of 4 mM.
M2724 Gliquidone Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.
M2181 ML133 hydrochloride ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels.
M2043 TAK-438 TAK-438 is a novel and potent potassium-competitive acid blocker (P-CAB) with IC50 of 19 nM.
M1797 Retigabine Retigabine is a KCNQ/Kv7 potassium channel activator which functions by enhancing potassium currents via stabilizing the open conformation of the Kv7.2-7.3 channels.

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