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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9820 | 2,2,2-Trichloroethanol | 2,2,2-Trichloroethanol is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). |
| M9780 | Nigericin | Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore. |
| M9700 | ML213 | ML213 (CID-3111211) is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener, with EC50 values of 230 and 510 nM for KV7.2 and KV7.4, respectively. |
| M9423 | CLP290 | CLP290 is a novel, orally available KCC2 modulator, highly selective for KCC2 over related Cl- transporters. |
| M9394 | BMS-191011 | BMS-191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). |
| M7926 | Minoxidil | Minoxidil activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth. |
| M7029 | Nigericin sodium salt | Nigericin sodium salt is a selective K+ ionophore. |
| M6975 | ML297 | ML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator. |
| M6052 | Vernakalant HCl | Vernakalant Hcl(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. |
| M5728 | Lansoprazole | Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid. |
| M5569 | Diazoxide | Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions. |
| M5437 | Azimilide | Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. |
| M5409 | Amiodarone | Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias. |
| M5368 | 4-Aminopyridine | 4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane. |
| M5302 | ICA069673 | ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM. |
| M4584 | Acacetin | Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects. |
| M3714 | Repaglinide | Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes. |
| M3622 | Vernakalant | Vernakalant (RSD-1235) is an investigational mixed ion channel blocker, which can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents. |
| M3456 | Chlorpromazine hydrochloride | Chlorpromazine hydrochloride is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for nward-rectifying K+ currents and time-independent outward currents |
| M3415 | Nateglinide | Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas. |
| M3399 | Gliclazide | Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. |
| M3343 | Nicorandil | Nicorandil is potassium channel activator. |
| M3192 | TRAM-34 | TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450. |
| M3077 | Tolbutamide | Tolbutamide is an inhibitor of cAMP with IC50 of 4 mM. |
| M2724 | Gliquidone | Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| M2181 | ML133 hydrochloride | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| M2043 | TAK-438 | TAK-438 is a novel and potent potassium-competitive acid blocker (P-CAB) with IC50 of 19 nM. |
| M1797 | Retigabine | Retigabine is a KCNQ/Kv7 potassium channel activator which functions by enhancing potassium currents via stabilizing the open conformation of the Kv7.2-7.3 channels. |
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