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Chlorpromazine hydrochloride

Cat. No. M3456
Chlorpromazine hydrochloride Structure
Synonym:

Sonazine

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 40  USD40 In stock
500mg USD 60  USD60 In stock
1g USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM). Chlorpromazine also excites the 20S proteasome. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.

*The compound is unstable in solutions, freshly prepared is recommended.

Product Citations
Chemical Information
Molecular Weight 355.33
Formula C17H19ClN2S.HCl
CAS Number 69-09-0
Form Solid
Solubility (25°C) Water 90 mg/mL
DMSO ≥ 60 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Oluwafemi E Kale, et al. Fundam Clin Pharmacol. Amlodipine, an L-type calcium channel blocker, protects against chlorpromazine-induced neurobehavioural deficits in mice

[2] R Tarazona, et al. J Immunol. Chlorpromazine amplifies macrophage-dependent IL-10 production in vivo

[3] M Balestrino, et al. Brain Res. Chlorpromazine protects brain tissue in hypoxia by delaying spreading depression-mediated calcium influx

[4] M Gadina, et al. J Exp Med. Protective effect of chlorpromazine on endotoxin toxicity and TNF production in glucocorticoid-sensitive and glucocorticoid-resistant models of endotoxic shock

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Keywords: Chlorpromazine hydrochloride, Sonazine supplier, Potassium Channel, inhibitors, activators


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