Free shipping on all orders over $ 500

Chlorpromazine hydrochloride

Cat. No. M3456
Chlorpromazine hydrochloride Structure
Synonym:

Sonazine

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 40 In stock
500mg USD 80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 uM for nward-rectifying K+ currents and time-independent outward currents. The turnover of dopamine in the brain is also increased. Chlorpromazine blocks a variety of K+ channels in heart muscle cells. Inasmuch as the potency of inhibition is less than the previously reported use-dependent block of Na+ channels, the cardiovascular adverse effects of chlorpromazine are probably caused mainly by the latter effect.

*The compound is unstable in solutions, freshly prepared is recommended.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 355.33
Formula C17H19ClN2S.HCl
CAS Number 69-09-0
Purity 99.86%
Solubility DMSO ≥ 60 mg/mL
Storage -20°C, protect from light, dry, sealed
Related Potassium Channel Products
Nigericin

Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore.

ML213

ML213 (CID-3111211) is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener, with EC50 values of 230 and 510 nM for KV7.2 and KV7.4, respectively.

CLP290

CLP290 is a novel, orally available KCC2 modulator, highly selective for KCC2 over related Cl- transporters.

BMS-191011

BMS-191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1).

Minoxidil

Minoxidil activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Chlorpromazine hydrochloride, Sonazine supplier, Potassium Channel, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.