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Potassium Channel Potassium channel

Cat.No.  Name Information
M4973 BAPTA-AM BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively.
M2181 ML133 hydrochloride ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels.
M3456 Chlorpromazine hydrochloride Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended
M7029 Nigericin sodium salt Nigericin (NSC 292567) sodium salt is a selective K+ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
M9423 CLP290 CLP290 is a novel, orally available KCC2 modulator, highly selective for KCC2 over related Cl- transporters.
M9394 BMS-191011 BMS-191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1).
M8906 Sematilide hydrochloride Sematilide (CK-1752) hydrochloride is a novel class III antiarrhythmic agent.
M8698 Kurarinone Kurarinone, a flavanone from Sophora flavescens roots, is a potent activator of the large-conductance calcium-activated potassium channel (BKCa channel).
M8223 VU591 VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590.
M7926 Minoxidil Minoxidil activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.
M7826 5-Hydroxydecanoic acid sodium salt 5-hydroxydecanoate (5-HD) blocks post-ischemic actions of the K+ channel activator cromakalim.
M7299 SKA 31 SKA 31 is a activator of K Ca3.1 and K Ca2 channels.
M7177 Quinine hydrochloride Quinine hydrochloride is the hydrochloride form of Quinine, an alkaloid extracted from the bark of the cinchona tree, with antimalarial and antitumor activities, and an IC50 value of 60 ng/mL against P. falciparum strains passou and 107.8 ng/mL against P. falciparum strain 3CD7, respectively, and an inhibitor of potassium channels. Quinine hydrochloride is also a potassium channel inhibitor that inhibits voltage pulse-induced MT mSlo3 (KCa5.1) channel +100 mV currents, with an IC50 value of 169 μM. In addition, Quinine hydrochloride binds to purine nucleoside phosphorylase (PfNP) and PfNP with low nanomolar affinity. nucleoside phosphorylase (PfPNP) with low nanomolar affinity.
M7103 Paxilline Paxilline is a sERCA ATPase blocker. Also potent BK Ca channel blocker.
M7052 NS 5806 NS 5806 is a k V4.3 channel activator.
M7029 Nigericin sodium salt Nigericin (NSC 292567) sodium salt is a selective K+ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
M6981 ML 365 ML 365 is a potent and selective K2P3.1 TASK-1 channel blocker.
M6975 ML297 ML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator.
M6906 Levcromakalim Levcromakalim is a k ir6 (K ATP) channel opener; active enantiomer of cromakalim.
M6735 Flupirtine maleate Flupirtine maleate is a selective potassium channel opener, NMDA receptor antagonist and GABAA receptor modulator.
M6580 Cesium chloride Cesium chloride is a potassium channel blocker; neuroprotective.
M6323 1-EBIO 1-EBIO is a activator of epithelial K Ca channels.
M6161 GSK369796 Dihydrochloride GSK369796 shows antimalerial activity with IC50 values of 11.2 nM for 3D7 strain, 12.6 nM for HB3 strain, 17.6 nM for K1 strain.
M6052 Vernakalant HCl Vernakalant Hcl(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.




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