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Amiodarone

Cat. No. M5409

Amiodarone  Structure
Size Price Availability Quantity
50mg USD 70 In stock
100mg USD 110 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 681.77
Formula C25H29I2NO3.HCl
CAS Number 19774-82-4
Purity >99%
Solubility 23 mg/mL in DMSO
Storage at -20°C
References

Herb-drug pharmacokinetic interaction between carica papaya extract and amiodarone in rats.
Rodrigues M, et al. J Pharm Pharm Sci. 2014;17(3):302-15. PMID: 25224345.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Amiodarone supplier, Potassium Channel, inhibitors

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