| Cat.No. | Name | Information |
|---|---|---|
| M4973 | BAPTA-AM | BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. |
| M2181 | ML133 hydrochloride | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| M3456 | Chlorpromazine hydrochloride | Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended |
| M7029 | Nigericin sodium salt | Nigericin (NSC 292567) sodium salt is a selective K+ ionophore, Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes. |
| M3415 | Nateglinide | Nateglinide is an orally active, short-acting insulin-releasing compound that is also an inhibitor of DPP IV. Nateglinide inhibits ATP-sensitive K+ channels in islet β cells. Nateglinide is available for the study of type 2 diabetes mellitus (non-insulin-dependent). |
| M3399 | Gliclazide | Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. |
| M3343 | Nicorandil | Nicorandil is potassium channel activator. |
| M3192 | TRAM-34 | TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450. |
| M3077 | Tolbutamide | Tolbutamide is an inhibitor of cAMP with IC50 of 4 mM, it is also an inhibitor of potassium channel, used for type II diabetes. |
| M3058 | Terfenadine | Terfenadine is an antihistamine compound that is normally fully metabolized in the liver by the cytochrome P450 CYP3A4 subtype enzyme into the active form fexofenadine. |
| M2946 | Pinacidil monohydrate | Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
| M2724 | Gliquidone | Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| M2649 | Doxapram hydrochloride | Doxapram hydrochloride inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| M2043 | TAK-438 | TAK-438 is a novel and potent potassium-competitive acid blocker (P-CAB) with IC50 of 19 nM. |
| M1797 | Retigabine | Retigabine is a KCNQ/Kv7 potassium channel activator which functions by enhancing potassium currents via stabilizing the open conformation of the Kv7.2-7.3 channels. |
| M1553 | 4-Hydroxytolbutamide | 4-Hydroxytolbutamide |
| M54578 | NPBA | NPBA is a potassium K2P channel TASK-3 (KCNK9) agonist and a tandem pore domain weak inward rectifier K+ channel (TWIK2) channel blocker. In addition, NPBA inhibits the activation of NLRP3 inflammasome in macrophages. |
| M54154 | BeKm-1 | BeKm-1 is a HERG (human ether-a-go-go-related gene) blocking compound. |
| M53944 | Apamin | Apamin (Apamine) is a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. |
| M53905 | Phe-Met-Arg-Phe amide trifluoroacetate | Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K+ current, with ED50 of 23 nM in the peptidergic caudodorsal neurons. |
| M53840 | Iberiotoxin | Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. |
| M52752 | Phe-Met-Arg-Phe, amide acetate | Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. |
| M52751 | Charybdotoxin | Charybdotoxin, a 37-amino acid peptide, is a K+ channel blocker. |
| M52750 | Agitoxin-2 | Agitoxin-2 is a K+ channel inhibitor, with IC50 values of 201 pM and 144 pM for mKV1.3 and mKV1.1, respectively). |
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