Free shipping on all orders over $ 500

Nigericin sodium salt

Cat. No. M7029
Nigericin sodium salt Structure
Synonym:

Sodium Nigericin

Size Price Availability Quantity
5mg USD 65 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nigericin sodium salt is a potassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin. Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 746.94
Formula C40H67NaO11
CAS Number 28643-80-3
Purity >98%
Solubility Ethanol ≥ 30 mg/mL
Storage 2-8°C, dry, protect from light, sealed
References

TLR4-dependent upregulation of the platelet NLRP3 inflammasome promotes platelet aggregation in a murine model of hindlimb ischemia
Sebastian Vogel, et al. Biochem Biophys Res Commun. 2019 Jan 8;508(2):614-619. PMID: 30522866.

Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy
Jun Ren, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):206-217. PMID: 30463689.

Activation of NLRP3 inflammasome in macrophages by mycoplasmal lipoproteins and lipopeptides
A Saeki, et al. Mol Oral Microbiol. 2018 Aug;33(4):300-311. PMID: 29682880.

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5
Paul J Baker, et al. Eur J Immunol. 2015 Oct;45(10):2918-26. PMID: 26173988.

Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.
Pulvino, et al. Blood. 2012;120: 1668. PMID: 22791293.

Related Potassium Channel Products
2,2,2-Trichloroethanol

2,2,2-Trichloroethanol is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).

Nigericin

Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore.

ML213

ML213 (CID-3111211) is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener, with EC50 values of 230 and 510 nM for KV7.2 and KV7.4, respectively.

CLP290

CLP290 is a novel, orally available KCC2 modulator, highly selective for KCC2 over related Cl- transporters.

BMS-191011

BMS-191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nigericin sodium salt, Sodium Nigericin supplier, Potassium Channel, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.