Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore. Nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions in Eukaryotic cells. Nigericin exhibits anticancer and anti-HIV activity.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Storage||2-8°C, dry, protect from light, sealed|
Inflammatory responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells stimulated with an inflammasome-inducing agent, nigericin
Soner Bilen, et al. Dev Comp Immunol. 2014 Oct;46(2):222-30. PMID: 24768998.
Nigericin selectively targets cancer stem cells in nasopharyngeal carcinoma
Cheng-Cheng Deng, et al. Int J Biochem Cell Biol. 2013 Sep;45(9):1997-2006. PMID: 23831840.
The K+-H+ exchanger, nigericin, modulates taste cell pH and chorda tympani taste nerve responses to acidic stimuli
Gregory R Sturz, et al. Chem Senses. 2011 May;36(4):375-88. PMID: 21257734.
Nigericin is a potent inhibitor of the early stage of vaccinia virus replication
Chad Myskiw, et al. Antiviral Res. 2010 Dec;88(3):304-10. PMID: 20951746.
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