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Nigericin

Cat. No. M9780
Nigericin Structure
Synonym:

Antibiotic K178, Antibiotic X464

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5mg USD 120 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Nigericin is an antibiotic derived from Streptomyces hygroscopicus, it acts as an H+, K+, Pb2+ ionophore. Nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions in Eukaryotic cells. Nigericin exhibits anticancer and anti-HIV activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 724.9
Formula C40H68O11
CAS Number 28380-24-7
Purity >98%
Solubility DMSO
Storage 2-8°C, dry, protect from light, sealed
References

Inflammatory responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells stimulated with an inflammasome-inducing agent, nigericin
Soner Bilen, et al. Dev Comp Immunol. 2014 Oct;46(2):222-30. PMID: 24768998.

Nigericin selectively targets cancer stem cells in nasopharyngeal carcinoma
Cheng-Cheng Deng, et al. Int J Biochem Cell Biol. 2013 Sep;45(9):1997-2006. PMID: 23831840.

The K+-H+ exchanger, nigericin, modulates taste cell pH and chorda tympani taste nerve responses to acidic stimuli
Gregory R Sturz, et al. Chem Senses. 2011 May;36(4):375-88. PMID: 21257734.

Nigericin is a potent inhibitor of the early stage of vaccinia virus replication
Chad Myskiw, et al. Antiviral Res. 2010 Dec;88(3):304-10. PMID: 20951746.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Nigericin, Antibiotic K178, Antibiotic X464 supplier, Potassium Channel, inhibitors

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