|M9125||Z-Guggulsterone||Z-Guggulsterone is a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM).|
|M9124||DY268||DY268 is a potent FXR antagonist with IC50 of 7.5 nM.|
|M9111||Nidufexor||Nidufexor is a farnesoid X receptor (FXR) agonist.|
|M9039||Cilofexor||Cilofexor is a farnesoid X receptor (FXR) agonist.|
|M6302||Fexaramine||Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds.|
|M6201||Tropifexor||Tropifexor is a novel and highly potent agonist of farnesoid X receptor (FXR).|
|M6157||PX-102||PX-102, also known as PX20606, is a FXR agonist.|
|M3775||Obeticholic Acid (INT-747)||Obeticholic Acid (INT-747) is a potent activator of the farnesoid X nuclear receptor that reduces liver fat and fibrosis in animal models of fatty liver disease.|
|M2507||Chenodiol||Chenodiol is an epimer of ursodeoxycholic acid, which inhibits the production of cholesterol in the liver and absorption in the intestines.|
|M2165||WAY-362450||WAY-362450 (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM.|
|M2018||GW4064||GW4064 is a selective, non-steroidal agonist of the orphan nuclear receptor FXR with EC50 of 15 nM.|
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