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Abmole Inhibitor Catalog 2017

Farnesoid X Receptor Farnesoid X Receptor


Cat.No.  Name Information
M10251 Gly-β-MCA Gly-β-MCA is a potent, stable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor.
M9597 Vonafexor Vonafexor is a farnesoid X receptor agonist.
M9125 Z-Guggulsterone Z-Guggulsterone is a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM).
M9124 DY268 DY268 is a potent FXR antagonist with IC50 of 7.5 nM.
M9111 Nidufexor Nidufexor is a farnesoid X receptor (FXR) agonist.
M9039 Cilofexor Cilofexor is a farnesoid X receptor (FXR) agonist.
M6302 Fexaramine Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds.
M6201 Tropifexor Tropifexor is a novel and highly potent agonist of farnesoid X receptor (FXR).
M6157 PX-102 PX-102, also known as PX20606, is a FXR agonist.
M3775 Obeticholic Acid (INT-747) Obeticholic Acid (INT-747) is a potent activator of the farnesoid X nuclear receptor that reduces liver fat and fibrosis in animal models of fatty liver disease.
M2507 Chenodeoxycholic acid Chenodeoxycholic acid is an epimer of ursodeoxycholic acid, which inhibits the production of cholesterol in the liver and absorption in the intestines.
M2165 WAY-362450 WAY-362450 (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM.
M2018 GW4064 GW4064 is a selective, non-steroidal agonist of the orphan nuclear receptor FXR with EC50 of 15 nM.

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