Free shipping on all orders over $ 500

WAY-362450

Cat. No. M2165

WAY-362450 Structure

Synonym: XL335

Size Price Availability Quantity
10mg USD 190 In stock
50mg USD 685 In stock
Bulk Inquiry?

Quality Control
Biological Activity

WAY-362450 (XL335) is a synthetic potent agonists of the farnesoid X receptor (FXR). WAY-362450 binds to the ligand-binding domain (LBD) of human FXR. WAY-362450 (XL335) also induced small heterodimer partner (SHP) expression and repressed cholesterol 7alpha-hydroxylase (CYP7A1) and sterol 12 alpha-hydroxylase (CYP8B1) expression. Oral administration of WAY-362450 to LDLR(-/-) mice results in lowering of cholesterol and triglycerides. Furthermore, treatment of wild type C57BL/6 mice with the FXR agonist WAY-362450, attenuated lipopolysaccharide-induced serum amyloid P component and serum amyloid A3 mRNA levels in the liver.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 438.47
Formula C25H24F2N2O3
CAS Number 629664-81-9
Purity 99.44%
Solubility DMSO 30 mg/mL
Storage at -20°C
References

Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis.
Zhang S, et al. J Hepatol. 2009 Aug;51(2):380-8. PMID: 19501927.

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice.
Hartman HB, et al. J Lipid Res. 2009 Jun;50(6):1090-100. PMID: 19174369.

Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR).
Flatt B, et al. J Med Chem. 2009 Feb 26;52(4):904-7. PMID: 19159286.

Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists.
Zhang S, et al. Biochem Biophys Res Commun. 2009 Feb 6;379(2):476-9. PMID: 19118524.

Related Farnesoid X Receptor Products
GW4064

GW4064 is a selective, non-steroidal agonist of the orphan nuclear receptor FXR with EC50 of 15 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: WAY-362450, XL335 supplier, Farnesoid X Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.