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Vonafexor

Cat. No. M9597
Vonafexor Structure
Synonym:

EYP001

Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 125  USD125 In stock
25mg USD 240  USD240 In stock
50mg USD 430  USD430 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Vonafexor is a farnesoid X receptor agonist. Vonafexor (EYP001) has anti-HBV effects.

Chemical Information
Molecular Weight 489.76
Formula C19H15Cl3N2O5S
CAS Number 1192171-69-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stefano Fiorucci, et al. Expert Opin Investig Dvqs. Bile Acid Modulators for the Treatment of Nonalcoholic Steatohepatitis (NASH)

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Keywords: Vonafexor, EYP001 supplier, Farnesoid X Receptor, inhibitors, activators


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