Free shipping on all orders over $ 500

Gly-β-MCA

Cat. No. M10251
Gly-β-MCA Structure
Synonym:

Glycine-β-muricholic Acid

Size Price Availability
5mg USD 380  USD380 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Gly-β-MCA is a potent, stable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor. Gly-β-MCA (Gly-MCA, 10 and 50 mg/kg; p.o.) prevents and treats diet-induced and genetic obesity, along with insulin resistance and hepatic steatosis without systemic, hepatic or intestinal toxicities in mice.

Chemical Information
Molecular Weight 465.62
Formula C26H43NO6
CAS Number 66225-78-3
Solubility (25°C) DMSO 100 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Changtao Jiang, et al. Nat Commun. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Related Farnesoid X Receptor Products
ASC-42

ASC-42 is a novel, potentially best-in-class, highly potent and selective non-steroidal FXR agonist that also inhibits the transcription of HBV RNA to hepatitis B surface antigen by inhibiting the transcription of HBV covalent closed-circle DNA (cccDNA) to HBV RNA.

Linafexor

Linafexor is a bile acid receptor (FXR) agonist that may be used in studies related to cholangitis and non-alcoholic steatohepatitis.

MET-409

MET-409 is an oral non-steroidal bile acid receptor FXR agonist for studies related to inflammatory bowel disease and irritable bowel syndrome.

FXR agonist 5

FXR agonist 5 is a FXR agonist.

XJ02862-S2

XJ02862-S2 shows potent FXR agonistic activity.

  Catalog
Abmole Inhibitor Catalog




Keywords: Gly-β-MCA, Glycine-β-muricholic Acid supplier, Farnesoid X Receptor, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.