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Fexaramine

Cat. No. M6302
Fexaramine Structure
Size Price Availability Quantity
10mg USD 180 In stock
50mg USD 600 In stock
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Quality Control
Biological Activity

Fexaramine significantly enhanced osteoblastic differentiation through the upregulation of Runx2 and enhanced extracellular signal-regulated kinase (ERK) and β-catenin signaling. By mimicking this tissue-selective effect, the gut-restricted FXR agonist fexaramine (Fex) robustly induces enteric fibroblast growth factor 15 (FGF15), leading to alterations in BA composition, but does so without activating FXR target genes in the liver.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 496.64
Formula C32H36N2O3
CAS Number 574013-66-4
Purity 99.36%
Solubility 10 mM in DMSO
Storage at -20°C
References

Positive regulation of osteogenesis by bile acid through FXR. J Bone Miner Res.
Cho SW, et al. J Bone Miner Res. 2013 Oct;28(10):2109-21.

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
Fang S, et al. Nat Med. 2015 Feb;21(2):159-65.

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  Catalog
Abmole Inhibitor Catalog 2017




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