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Nidufexor

Cat. No. M9111
Nidufexor Structure
Synonym:

LMB-763

Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 240  USD240 In stock
25mg USD 420  USD420 In stock
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Quality Control & Documentation
Biological Activity

Nidufexor is a farnesoid X receptor (FXR) agonist.

Chemical Information
Molecular Weight 487.93
Formula C27H22ClN3O4
CAS Number 1773489-72-7
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stefano Fiorucci, et al. The identification of farnesoid X receptor modulators as treatment options for nonalcoholic fatty liver disease

[2] Stefano Fiorucci, et al. Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH)

[3] Donatella Chianelli, et al. Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis

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Keywords: Nidufexor, LMB-763 supplier, Farnesoid X Receptor, inhibitors, activators


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