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DY268

Cat. No. M9124
DY268 Structure
Synonym:

DY 268

Size Price Availability
2mg USD 300 1-2 Weeks
5mg USD 360 1-2 Weeks
10mg USD 630 1-2 Weeks
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

DY268 is a potent FXR antagonist with IC50 of 7.5 nM. DY 268 exhibits no detectable cytotoxicity in cell-based assays.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 560.66
Formula C30H32N4O5S
CAS Number 1609564-75-1
Purity >98%
Solubility DMSO: ≥ 40 mg/mL
Storage at -20°C
References

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor.
Yu DD, et al. Bioorg Med Chem. 2014 Jun 1;22(11):2919-38. PMID: 24775917.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: DY268, DY 268 supplier, Farnesoid X Receptor, inhibitors

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