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Cytochrome P450 (e.g. CYP17) Cytochrome P450 (e.g. CYP17)

Inhibitors

Cat.No.  Name Information
M3326 Memantine hydrochloride Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
M14316 Schisandrin A Schisandrin A inhibits CYP3A activity with an IC50 of 6.60 μM and Ki of 5.83 μM, respectively.
M14315 Pradefovir mesylate Pradefovir mesylate is a good substrate for liver CYP3A4. Pradefovir is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with a Km of 60 μM.
M14314 N-Nornuciferine N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively.
M14313 Friedelin Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart).
M14312 Curcumenol Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities.
M14311 Cecropin B Cecropin B has high level of antimicrobial activity and is considered as a valuable peptide antibiotic.
M14310 Bergamottin Bergamottin is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM.
M11528 Naringin Naringin, a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.
M11176 Tebuconazole Tebuconazole is an agricultural azole fungicide that also inhibits CYP51 for Candida albicans CYP51 (CaCYP51) and truncated human CYP51 (Δ60HsCYP51). IC50 The values are 0.9 and 1.3 μM, respectively.
M11149 Uniconazole Uniconazole is a plant growth regulator that inhibits cytochrome P450 707As (Ki=68 nM) plays a role, which is a family of enzymes that separate abscisic acid and therefore inhibits the biosynthesis of gibberellin and sterols.
M11137 Dihydromethysticin Dihydroestherol (Dihydromethysticin) kava lactone, with induced CYP3A23 activity.
M10656 Bergaptol Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.
M9931 ε-​Viniferin ε-Viniferin is a potent inhibitor for all the CYP family, with Ki values from 0.5-20 μM.
M9877 Rhapontigenin Rhapontigenin is a selective inactivator of cytochrome P450 1A1 with IC50 of 400 nM.
M9684 (Rac)-Brassinazole (Rac)-Brassinazole is a brassinosteroid (BR) biosynthesis inhibitor.
M8186 Stiripentol Stiripentol (BCX2600) can be used in the study of the third generation of antiepileptic drugs that enhance gaba energy neurotransmission. It's an inhibitor of cytochrome P450.
M6451 Apigenin Apigenin is a protein kinase inhibitor.
M6389 1-Aminobenzotriazole (ABT) 1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor; inhibits 20-HETE synthesis.
M5650 Fluconazole Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.
M5059 Furafylline Furafylline was a potent, non-competitive inhibitor of high affinity phenacetin O-deethylase activity of microsomal fractions of human liver, a reaction catalysed by P450IA2, with an IC50 value of 0.07 microM.



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