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Dihydromethysticin

Cat. No. M11137
Dihydromethysticin  Structure
Size Price Availability Quantity
5mg USD 245  USD245 In stock
10mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Dihydroestherol (Dihydromethysticin) kava lactone, with induced CYP3A23 activity.

Chemical Information
Molecular Weight 276.28
Formula C15H16O5
CAS Number 19902-91-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qi Hu, et al. Chem Res Toxicol. Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice

[2] Huayang Pan, et al. Mol Carcinog. Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway

[3] Sreekanth C Narayanapillai, et al. Drug Metab Dispos. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

[4] Jun-Qi Dai, et al. Int J Clin Exp Pathol. Dihydromethysticin kavalactone induces apoptosis in osteosarcoma cells through modulation of PI3K/Akt pathway, disruption of mitochondrial membrane potential and inducing cell cycle arrest

[5] Yan Li, et al. Toxicol Sci. Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1

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Keywords: Dihydromethysticin supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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