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Bergamottin

Cat. No. M14310
Bergamottin Structure
Synonym:

5-Geranoxypsoralen; Bergamotine; Bergaptin

Size Price Availability Quantity
1mg USD 50  USD50 In stock
5mg USD 103  USD103 In stock
10mg USD 180  USD180 In stock
20mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Bergamottin is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM.

Chemical Information
Molecular Weight 338.4
CAS Number 7380-40-7
Solubility (25°C) DMSO 50 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ning An, et al. Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-κB

[2] Opalina Vetrichelvan, et al. Bergamottin a CYP3A inhibitor found in grapefruit juice inhibits prostate cancer cell growth by downregulating androgen receptor signaling and promoting G0/G1 cell cycle block and apoptosis

[3] Ying Liu, et al. Mechanistic study of bergamottin-induced inactivation of CYP2C9

[4] Hui-Juan Wu, et al. [Retracted] Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and i䲧璵Ỵ璶

[5] Kei Suzuki, et al. Bergamottin can be used to assess CYP3A-mediated intestinal first-pass metabolism without affecting P-glycoprotein-mediated efflux in rats

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  Catalog
Abmole Inhibitor Catalog




Keywords: Bergamottin, 5-Geranoxypsoralen; Bergamotine; Bergaptin supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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