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Memantine hydrochloride

Cat. No. M3326
Memantine hydrochloride Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL In DMSO USD 80 In stock
1g USD 85 In stock
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Quality Control
Biological Activity

Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 215.76
Formula C12H21N.HCl
CAS Number 41100-52-1
Purity >99%
Solubility DMSO 40 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source Discov Med (2017). Figure 5. Memantine (Abmole Bioscience, Houston, TX)
Method Western blot
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results PTZ-kindled rats had increased level of Cdk5 in white matters, memantine, ifenprodil, lithium chloride (LiCl), and roscovitine decreased Cdk5 in PTZ-kindled rats.
Rating
Source Discov Med (2017). Figure 4. Memantine (Abmole Bioscience, Houston, TX)
Method Immunohistochemistry
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Representative immunohistochemical microphotographs showed increased accumulation of APP in corpus callosum in PTZ-kindled rats. Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated the accumulation.
Rating
Source Discov Med (2017). Figure 3. Memantine (Abmole Bioscience, Houston, TX)
Method Immunohistochemistry
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated such reduction.
Rating
Source Discov Med (2017). Figure 2. Memantine (Abmole Bioscience, Houston, TX)
Method Western blotting
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Memantine, ifenprodil, and LiCl increased tau in PTZ-kindled rats and decreased relative tau phosphorylation level, but failed to decrease p-tau S396 and p-tau T231.
Rating
Product Citations
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Memantine hydrochloride supplier, inhibitors

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