Free shipping on all orders over $ 500

Memantine hydrochloride

Cat. No. M3326

Memantine hydrochloride Structure
Size Price Availability Quantity
1g USD 85 In stock
5g USD 150 In stock
Bulk Inquiry?

Quality Control
Biological Activity

Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 215.76
Formula C12H21N.HCl
CAS Number 41100-52-1
Purity >99%
Solubility DMSO 40 mg/mL
Storage at -20°C
Customer Product Validation
Source Discov Med (2017). Figure 5. Memantine (Abmole Bioscience, Houston, TX)
Method Western blot
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results PTZ-kindled rats had increased level of Cdk5 in white matters, memantine, ifenprodil, lithium chloride (LiCl), and roscovitine decreased Cdk5 in PTZ-kindled rats.
Rating
Source Discov Med (2017). Figure 4. Memantine (Abmole Bioscience, Houston, TX)
Method Immunohistochemistry
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Representative immunohistochemical microphotographs showed increased accumulation of APP in corpus callosum in PTZ-kindled rats. Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated the accumulation.
Rating
Source Discov Med (2017). Figure 3. Memantine (Abmole Bioscience, Houston, TX)
Method Immunohistochemistry
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated such reduction.
Rating
Source Discov Med (2017). Figure 2. Memantine (Abmole Bioscience, Houston, TX)
Method Western blotting
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Memantine, ifenprodil, and LiCl increased tau in PTZ-kindled rats and decreased relative tau phosphorylation level, but failed to decrease p-tau S396 and p-tau T231.
Rating
Product Citations
Related Products
Calicheamicins

The calicheamicins are a class of enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora, with calicheamicin γ1 being the most notable.

Tildipirosin

Tildipirosin is a derivative of the naturally occurring compound tylosin.

Oritavancin diphosphate

Oritavancin is approved for the treatment of adult patients with acute bacterial skin and skin structure infections (SSSIs) caused by or suspected to be caused by susceptible isolates of designated gram-positive microorganisms.

ECBN HCL

ECBN obtained by the fermentation of Aspergillus nidulans and Aspergillus rugulosus, is known as one of the natural cyclic hexapeptides that have a linoleoyl side chain, which inhibits a crucial enzyme in fungal cell wall biosynthesis, β-(1,3)-d-glucan synthase.

Pristinamycin

The pristinamycins exhibit a strong synergistic antibacterial activity against a wide range of Gram-positive and some Gram-negative bacteria, including methicillin- and vancomycin-resistant strains.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Memantine hydrochloride supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.