Memantine hydrochloride (Memantine HCl) is the hydrochloride salt of Memantine, also a voltage-dependent, non-competitive NMDA receptor antagonist.Memantine binds to and inhibits the cation channel of the NMDA receptor, inhibiting the sustained influx of calcium ions and the associated neuronal excitotoxicity. In addition, Memantine is also an inhibitor of 5-hydroxytryptamine type 3 (5HT3) receptors, nicotinic acetylcholine receptor (nAChR), CYP2B6 and CYP2D6, acting on recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
Discov Med. 2017 Apr;23(127):221-234.
N-methyl-D-aspartate Receptors Mediate Epilepsy-Induced Axonal Impairment and Tau Phosphorylation via Activating Glycogen Synthase Kinase-3β and Cyclin-dependent Kinase 5
Memantine hydrochloride purchased from AbMole
Molecular Weight | 215.76 |
Formula | C12H21N.HCl |
CAS Number | 41100-52-1 |
Solubility (25°C) | Water 27 mg/mL DMSO 30 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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