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Memantine hydrochloride

Cat. No. M3326
Memantine hydrochloride Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 40  USD40 In stock
200mg USD 40  USD40 In stock
500mg USD 50  USD50 In stock
1g USD 65  USD65 In stock
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Quality Control & Documentation
Biological Activity

Memantine hydrochloride (Memantine HCl) is the hydrochloride salt of Memantine, also a voltage-dependent, non-competitive NMDA receptor antagonist.Memantine binds to and inhibits the cation channel of the NMDA receptor, inhibiting the sustained influx of calcium ions and the associated neuronal excitotoxicity. In addition, Memantine is also an inhibitor of 5-hydroxytryptamine type 3 (5HT3) receptors, nicotinic acetylcholine receptor (nAChR), CYP2B6 and CYP2D6, acting on recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

Product Citations
Customer Product Validations & Biological Datas
Source Discov Med (2017). Figure 5. Memantine (Abmole Bioscience, Houston, TX)
Method Western blot
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results PTZ-kindled rats had increased level of Cdk5 in white matters, memantine, ifenprodil, lithium chloride (LiCl), and roscovitine decreased Cdk5 in PTZ-kindled rats.
Source Discov Med (2017). Figure 4. Memantine (Abmole Bioscience, Houston, TX)
Method Immunohistochemistry
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Representative immunohistochemical microphotographs showed increased accumulation of APP in corpus callosum in PTZ-kindled rats. Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated the accumulation.
Source Discov Med (2017). Figure 3. Memantine (Abmole Bioscience, Houston, TX)
Method Immunohistochemistry
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated such reduction.
Source Discov Med (2017). Figure 2. Memantine (Abmole Bioscience, Houston, TX)
Method Western blotting
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Memantine, ifenprodil, and LiCl increased tau in PTZ-kindled rats and decreased relative tau phosphorylation level, but failed to decrease p-tau S396 and p-tau T231.
Chemical Information
Molecular Weight 215.76
Formula C12H21N.HCl
CAS Number 41100-52-1
Solubility (25°C) Water 27 mg/mL
DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] H S Chen, et al. J Physiol. Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism

[2] H S Chen, et al. J Neurosci. Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

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Keywords: Memantine hydrochloride supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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