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Abmole Inhibitor Catalog 2017

CYP17 Cytochrome P450 17

Inhibitors

Cat.No.  Name Information
M4000 Naringenin Naringenin, a common dietary flavonoid abundantly present in fruits and vegetables, is believed to possess strong anti-proliferative properties and the ability to induce apoptosis in hepatoma cell lines.
M3953 Voriconazole Voriconazole is an inhibitor of 14α-lanosterol demethylase with IC50 value of 53nM.
M3708 Anastrozole Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis.
M3591 Abiraterone Acetate Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM.
M2206 TH-302 TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM.
M2058 Ketoconazole Ketoconazole is a potent inhibitor of cytochrome P450c17.
M1839 MDV3100 MDV3100 is an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity.
M1814 Avasimibe Avasimibe (CI-1011) is a novel orally bioavailable ACAT inhibitor with IC50 values of 2.9, 13.9, 26.5 µM for CYP2C9, CYP1A2 and CYP2C19, respectively.
M1636 Abiraterone Abiraterone acetate (CB-7598) is a potent, selective, and orally available inhibitor of CYP17 with an IC50 of 4 nM.


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