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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M3326 | Memantine hydrochloride | Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively. |
| M11176 | Tebuconazole | Tebuconazole is an agricultural azole fungicide that also inhibits CYP51 for Candida albicans CYP51 (CaCYP51) and truncated human CYP51 (Δ60HsCYP51). IC50 The values are 0.9 and 1.3 μM, respectively. |
| M11149 | Uniconazole | Uniconazole is a plant growth regulator that inhibits cytochrome P450 707As (Ki=68 nM) plays a role, which is a family of enzymes that separate abscisic acid and therefore inhibits the biosynthesis of gibberellin and sterols. |
| M11137 | Dihydromethysticin | Dihydroestherol (Dihydromethysticin) kava lactone, with induced CYP3A23 activity. |
| M10656 | Bergaptol | Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. |
| M9931 | ε-Viniferin | ε-Viniferin is a potent inhibitor for all the CYP family, with Ki values from 0.5-20 μM. |
| M9877 | Rhapontigenin | Rhapontigenin is a selective inactivator of cytochrome P450 1A1 with IC50 of 400 nM. |
| M9684 | (Rac)-Brassinazole | (Rac)-Brassinazole is a brassinosteroid (BR) biosynthesis inhibitor. |
| M8186 | Stiripentol | Stiripentol (BCX2600) can be used in the study of the third generation of antiepileptic drugs that enhance gaba energy neurotransmission. It's an inhibitor of cytochrome P450. |
| M6451 | Apigenin | Apigenin is a protein kinase inhibitor. |
| M6389 | 1-Aminobenzotriazole (ABT) | 1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor; inhibits 20-HETE synthesis. |
| M5650 | Fluconazole | Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections. |
| M5059 | Furafylline | Furafylline was a potent, non-competitive inhibitor of high affinity phenacetin O-deethylase activity of microsomal fractions of human liver, a reaction catalysed by P450IA2, with an IC50 value of 0.07 microM. |
| M4699 | Galangin | Galangin (Norizalpinin) is a regulator of arylhydrocarbon receptors and also inhibits the activity of CYP1A1. |
| M4595 | Isosilybin | Isosilybin (Isosilybinin) is a flavonoid from milk thistle; The IC50 value induced by CYP3A4 inhibition was 74 μM. |
| M4573 | Diosmetin | Diosmetin is a natural flavonoid that inhibits the activity of human CYP1A enzyme. The IC50 value of Diosmetin in HepG2 cells is 40 μM. |
| M4495 | Linderane | Linderane was isolated from Lindera Strychnifolia and is an irreversible inhibitor of Cytochrome P450 2C9 (CYP2C9). Linderane has been shown to relieve pain and cramps. |
| M4414 | Gentiopicrin | Gentiopicroside is a natural iridoid glycoside that can inhibit the activity of P450 with IC50 and Ki values of 61 µM and 22.8 µM for CYP2A6, respectively. Gentiopicroside has anti-inflammatory and antioxidant activities. |
| M4376 | Forsythin | Phillyrin is isolated from forsythia and has antibacterial and anti-inflammatory properties. Phillyrin can potentially induce CYP1A2 and CYP2D1 in rats, but does not affect THE activities of CYP2C11 and CYP3A1/2. Phillyrin has activity against influenza A virus. |
| M4191 | Polygalaxanthone-III | Polygalaxanthone III was extracted from Polygala Tenuifolia Wild and had inhibitory effects on CYP450. Polygalaxanthone III inhibited the 6-hydroxylation of clozoxazone catalyzed by CYP2E1 with IC50 of 50.56μM. |
| M4146 | Sodium-Danshensu | Danshensu (sodium) is the active component of salvia miltiorrhiza, which can inhibit the formation of reactive oxygen species, inhibit platelet adhesion and aggregation, and protect myocardial ischemia. |
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