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Bergaptol

Cat. No. M10656
Bergaptol Structure
Synonym:

4-Hydroxybergapten; 5-Hydroxypsoralen

Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 210  USD210 In stock
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Quality Control & Documentation
Biological Activity

Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.

Chemical Information
Molecular Weight 202.16
Formula C11H6O4
CAS Number 486-60-2
Solubility (25°C) DMSO 30 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chun-Yan Shen, et al. Food Funct. Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition

[2] Yucheng Zhao, et al. J Adv Res. Structure-based tailoring of the first coumarins-specific bergaptol O-methyltransferase to synthesize bergapten for depigmentation disorder treatment

[3] Yucheng Zhao, et al. Front Plant Sci. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn

[4] Aya Ishikawa, et al. Plant Cell Rep. Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures

[5] G RODIGHIERO, et al. Farmaco Sci. [Bergaptol ethers]

Related Cytochrome P450 (e.g. CYP17) Products
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Cytochrome P450 reductase is a NADPH-cytochrome reductase.

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Abiraterone decanoate is a novel, long-acting Abiraterone precursor compound that also exhibits high CYP17 cleavage enzyme inhibition selectivity for prostate cancer related studies.

  Catalog
Abmole Inhibitor Catalog




Keywords: Bergaptol, 4-Hydroxybergapten; 5-Hydroxypsoralen supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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