About 7 results found for searched term "USP1-IN-6" (0.137 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41456 | USP1-IN-6 | Deubiquitinase |
| USP1-IN-6 is a USP1 inhibitor (IC50<50 nM). | ||
| M9785 | ML364 | Deubiquitinase |
| ML-364 | ||
| ML364 is a small molecule inhibitor of the deubiquitinase USP2 (IC50=1.1 μM, Kd=5.2 μM) with potential anticancer activity. ML364 induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP. | ||
| M10504 | IU1-47 | Deubiquitinase |
| IU 1-47 | ||
| IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. | ||
| M20734 | (E/Z)-BCI | Phosphatase |
| BCI, NSC 150117 | ||
| (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. | ||
| M24949 | Clervonafusp alfa | Others |
| VAL-1221 | ||
| Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs). Clervonafusp alfa can be used for late-onset Pompe disease research. | ||
| M40720 | I-138 | Deubiquitinase |
| I-138 is an orally active, potent reversible inhibitor of USP1-UAF1, structurally related to ML323, showing synergistic binding to ubiquitin and mutually exclusive binding to ML323. I-138 induces mono-ubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 mono-ubiquitination in HAP-1 USP1 WT cells, and abrogates USP1 auto-cleavage in cells. | ||
| M41451 | USP7-IN-12 | Deubiquitinase |
| USP7-IN-12 is a potent and orally active Usp7 inhibitor with an IC50 value of 3.67 nM. | ||
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