About 6 results found for searched term "USP1-IN-6" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41456 | USP1-IN-6 | Deubiquitinase |
| USP1-IN-6 is a USP1 inhibitor (IC50<50 nM). | ||
| M10504 | IU1-47 | Deubiquitinase |
| IU 1-47 | ||
| IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. | ||
| M20734 | (E/Z)-BCI | Phosphatase |
| BCI, NSC 150117 | ||
| (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. | ||
| M24949 | Clervonafusp alfa | Others |
| VAL-1221 | ||
| Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs). Clervonafusp alfa can be used for late-onset Pompe disease research. | ||
| M40720 | I-138 | Deubiquitinase |
| I-138 is an orally active, potent reversible inhibitor of USP1-UAF1, structurally related to ML323, showing synergistic binding to ubiquitin and mutually exclusive binding to ML323. I-138 induces mono-ubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 mono-ubiquitination in HAP-1 USP1 WT cells, and abrogates USP1 auto-cleavage in cells. | ||
| M41451 | USP7-IN-12 | Deubiquitinase |
| USP7-IN-12 is a potent and orally active Usp7 inhibitor with an IC50 value of 3.67 nM. | ||
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