About 6 results found for searched term "USP1-IN-4" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41452 | USP1-IN-4 | Deubiquitinase |
| USP1-IN-4 is an effective USP1 inhibitor with an IC50 value of 2.44 nM. | ||
| M9785 | ML364 | Deubiquitinase |
| ML-364 | ||
| ML364 is a small molecule inhibitor of the deubiquitinase USP2 (IC50=1.1 μM, Kd=5.2 μM) with potential anticancer activity. ML364 induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP. | ||
| M10751 | USP7-IN-8 | Deubiquitinase |
| USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in the Ub-Rho110 assay.USP7-IN-8 is inactive against USP47 and USP5.USP7-IN-8 has anticancer effects. | ||
| M24993 | Cinrebafusp alfa | EGFR/HER2 |
| PRS 343 | ||
| Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research. | ||
| M40720 | I-138 | Deubiquitinase |
| I-138 is an orally active, potent reversible inhibitor of USP1-UAF1, structurally related to ML323, showing synergistic binding to ubiquitin and mutually exclusive binding to ML323. I-138 induces mono-ubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 mono-ubiquitination in HAP-1 USP1 WT cells, and abrogates USP1 auto-cleavage in cells. | ||
| M54866 | Recombinant Human USP14 (E.coli, N-6His) | Cytokines and Growth Factors |
| Ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14 | ||
| USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
